Systemic Cytokine Profiles of CD4+ T Lymphocytes Correlate with Clinical Features and Functional Status in Stable COPD.
chronic obstructive pulmonary disease
flow cytometry
inflammation
phenotype
Journal
International journal of chronic obstructive pulmonary disease
ISSN: 1178-2005
Titre abrégé: Int J Chron Obstruct Pulmon Dis
Pays: New Zealand
ID NLM: 101273481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
06
2020
accepted:
20
08
2020
entrez:
23
11
2020
pubmed:
24
11
2020
medline:
29
6
2021
Statut:
epublish
Résumé
To evaluate the expressions of intracellular cytokines in CD4+ T lymphocytes and to investigate the correlation between biomarker expressions and clinical and functional characteristics of stable COPD patients. Peripheral blood was collected from 36 COPD patients, and the expression of cytokines (IL-8, IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-α) in T lymphocytes CD4 + was investigated. In addition, lung function, dyspnea symptoms, quality of life, vital signs, body composition, level of physical activity, peripheral muscle strength, and functional capacity were assessed. Individuals with greater bronchial obstruction present a higher proportion of CD4 + IL-2 + lymphocytes compared to individuals with less severe bronchial obstruction. We found a positive correlation between the expression of the cytokines IL-13, IL-17, IL-6, IL-2, IL-10, and TNF-α in CD4+ T lymphocytes. In addition, we found a positive correlation between CD4+ IL-10+ T lymphocytes and lower limb muscle strength and a negative correlation between CD4+ IL-8+ T lymphocytes and peripheral oxygen saturation and steps per day. Systemic CD4+IL-2+, IL-8+, and IL-10+ T lymphocytes presented a correlation with clinical characteristics and functional status in stable COPD.
Identifiants
pubmed: 33223825
doi: 10.2147/COPD.S268955
pii: 268955
pmc: PMC7671532
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2931-2940Informations de copyright
© 2020 Uzeloto et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Respirology. 2020 Jan;25(1):47-48
pubmed: 31373083
J Bras Pneumol. 2009 Aug;35(8):737-44
pubmed: 19750325
J Immunol. 2008 May 1;180(9):5771-7
pubmed: 18424693
Chest. 2020 May;157(5):1147-1157
pubmed: 31887283
Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619866096
pubmed: 31390957
Methods Mol Med. 2002;72:423-35
pubmed: 12125138
Curr Opin Immunol. 2011 Oct;23(5):598-604
pubmed: 21889323
Clin Exp Immunol. 2009 Aug;157(2):316-24
pubmed: 19604272
Pathol Res Pract. 2019 Jan;215(1):97-105
pubmed: 30392917
Respir Res. 2019 Jul 30;20(1):171
pubmed: 31362724
Am J Respir Cell Mol Biol. 2018 Apr;58(4):500-509
pubmed: 29206476
Eur Respir J. 2014 Dec;44(6):1428-46
pubmed: 25359355
Eur Respir J. 2012 Aug;40(2):330-7
pubmed: 22183488
Chron Respir Dis. 2019 Jan-Dec;16:1479973119843650
pubmed: 31131626
Sci Immunol. 2018 Jul 6;3(25):
pubmed: 29980618
Am J Respir Crit Care Med. 2002 Sep 15;166(6):809-13
pubmed: 12231489
J Immunol Methods. 2019 Jan;464:131-137
pubmed: 30395817
PLoS Med. 2004 Oct;1(1):e8
pubmed: 15526056
Thorax. 2007 Feb;62(2):115-20
pubmed: 17090575
Immunol Lett. 2018 Apr;196:1-10
pubmed: 29329680
Clin Exp Allergy. 2010 Jan;40(1):42-9
pubmed: 19878194
Int J Chron Obstruct Pulmon Dis. 2018 Aug 20;13:2483-2494
pubmed: 30154651
Clin Rehabil. 2014 Nov;28(11):1096-106
pubmed: 24647863
Int J Chron Obstruct Pulmon Dis. 2017 Feb 20;12:669-675
pubmed: 28255238
Int J Chron Obstruct Pulmon Dis. 2015 Aug 06;10:1553-8
pubmed: 26345641
Int J Chron Obstruct Pulmon Dis. 2020 Mar 31;15:681-690
pubmed: 32280207
Malawi Med J. 2012 Sep;24(3):69-71
pubmed: 23638278
BMJ Open Respir Res. 2019 May 4;6(1):e000431
pubmed: 31258919
J Allergy Clin Immunol. 2016 Jul;138(1):16-27
pubmed: 27373322
Nat Rev Immunol. 2018 Jul;18(7):454-466
pubmed: 29626211
PLoS One. 2016 Apr 22;11(4):e0150586
pubmed: 27104349
Respir Res. 2017 Oct 24;18(1):180
pubmed: 29065892
Adv Respir Med. 2019;87(3):159-166
pubmed: 31282557
Pulmonology. 2020 Mar - Apr;26(2):95-100
pubmed: 31740261
Int J Chron Obstruct Pulmon Dis. 2020 Feb 26;15:439-460
pubmed: 32161455
Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L24-39
pubmed: 26498252
BMC Pulm Med. 2019 Jul 26;19(1):137
pubmed: 31349846
Mediators Inflamm. 2016;2016:3604842
pubmed: 27524865
Eur Respir J. 2017 Oct 12;50(4):
pubmed: 29025886
Am J Respir Crit Care Med. 2019 May 15;199(10):1195-1204
pubmed: 30592902
Braz J Med Biol Res. 1999 Jun;32(6):703-17
pubmed: 10412549
Immunol Lett. 2010 Jun 15;131(1):97-105
pubmed: 20206208
Respir Res. 2007 Sep 14;8:64
pubmed: 17868461
BMC Pulm Med. 2016 Dec 3;16(1):173
pubmed: 27914470
Cytokine. 2018 Jun;106:95-100
pubmed: 29108795
J Bras Pneumol. 2008 Dec;34(12):1008-18
pubmed: 19180335