Genomic characterization of HIV-associated plasmablastic lymphoma identifies pervasive mutations in the JAK-STAT pathway.
CD44
Epstein Barr virus
JAK-STAT
genetics
plasmablastic lymphoma
Journal
Blood cancer discovery
ISSN: 2643-3249
Titre abrégé: Blood Cancer Discov
Pays: United States
ID NLM: 101764786
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
entrez:
23
11
2020
pubmed:
24
11
2020
medline:
24
11
2020
Statut:
ppublish
Résumé
Plasmablastic lymphoma (PBL) is an aggressive B-cell non-Hodgkin lymphoma associated with immunodeficiency in the context of Human Immunodeficiency Virus (HIV) infection or iatrogenic immunosuppression. While a rare disease in general, the incidence is dramatically increased in regions of the world with high HIV prevalence. The molecular pathogenesis of this disease is poorly characterized. Here, we defined the genomic features of PBL in a cohort of 110 patients from South Africa (15 by whole exome sequencing and 95 by deep targeted sequencing). We identified recurrent mutations in genes of the JAK-STAT signaling pathway, including
Identifiants
pubmed: 33225311
doi: 10.1158/2643-3230.BCD-20-0051
pii: 2643-3230.BCD-20-0051
pmc: PMC7679070
mid: NIHMS1627159
doi:
Substances chimiques
STAT Transcription Factors
0
Janus Kinases
EC 2.7.10.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
112-125Subventions
Organisme : NCI NIH HHS
ID : D43 CA153715
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117591
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA192854
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA193313
Pays : United States
Commentaires et corrections
Type : CommentIn
Déclaration de conflit d'intérêts
A conflict of interest disclosure statement: R.R. is a consultant for AimedBio in a project unrelated to the current manuscript.
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