Are Financial Payments From the Pharmaceutical Industry Associated With Physician Prescribing? : A Systematic Review.
Journal
Annals of internal medicine
ISSN: 1539-3704
Titre abrégé: Ann Intern Med
Pays: United States
ID NLM: 0372351
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
pubmed:
24
11
2020
medline:
23
3
2021
entrez:
23
11
2020
Statut:
ppublish
Résumé
Financial payments from the drug industry to U.S. physicians are common. Payments may influence physicians' clinical decision making and drug prescribing. To evaluate whether receipt of payments from the drug industry is associated with physician prescribing practices. MEDLINE (Ovid), Embase, the Cochrane Library, Web of Science, and EconLit were searched without language restrictions. The search had no limiting start date and concluded on 16 September 2020. Studies that estimated the association between receipt of industry payments (exposure) and prescribing (outcome). Pairs of reviewers extracted the primary analysis or analyses from each study and evaluated risk of bias (ROB). Thirty-six studies comprising 101 analyses were included. Most studies ( The design was observational, 21 of 36 studies had serious ROB, and publication bias was possible. The association between industry payments and physician prescribing was consistent across all studies that have evaluated this association. Findings regarding a temporal association and dose-response suggest a causal relationship. National Cancer Institute.
Sections du résumé
BACKGROUND
Financial payments from the drug industry to U.S. physicians are common. Payments may influence physicians' clinical decision making and drug prescribing.
PURPOSE
To evaluate whether receipt of payments from the drug industry is associated with physician prescribing practices.
DATA SOURCES
MEDLINE (Ovid), Embase, the Cochrane Library, Web of Science, and EconLit were searched without language restrictions. The search had no limiting start date and concluded on 16 September 2020.
STUDY SELECTION
Studies that estimated the association between receipt of industry payments (exposure) and prescribing (outcome).
DATA EXTRACTION
Pairs of reviewers extracted the primary analysis or analyses from each study and evaluated risk of bias (ROB).
DATA SYNTHESIS
Thirty-six studies comprising 101 analyses were included. Most studies (
LIMITATION
The design was observational, 21 of 36 studies had serious ROB, and publication bias was possible.
CONCLUSION
The association between industry payments and physician prescribing was consistent across all studies that have evaluated this association. Findings regarding a temporal association and dose-response suggest a causal relationship.
PRIMARY FUNDING SOURCE
National Cancer Institute.
Identifiants
pubmed: 33226858
doi: 10.7326/M20-5665
pmc: PMC8315858
mid: NIHMS1722666
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
353-361Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
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