Oxytocin at elective caesarean delivery: a dose-finding study in women with obesity.
Adult
Body Mass Index
Cesarean Section
Dose-Response Relationship, Drug
Double-Blind Method
Elective Surgical Procedures
Female
Humans
Obesity
/ physiopathology
Oxytocics
/ administration & dosage
Oxytocin
/ administration & dosage
Postpartum Hemorrhage
/ physiopathology
Pregnancy
Prospective Studies
Uterine Contraction
/ drug effects
Uterus
/ drug effects
caesarean delivery
obesity
oxytocin
postpartum haemorrhage
uterotonic drug
Journal
Anaesthesia
ISSN: 1365-2044
Titre abrégé: Anaesthesia
Pays: England
ID NLM: 0370524
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
20
07
2020
accepted:
19
10
2020
pubmed:
24
11
2020
medline:
22
6
2021
entrez:
23
11
2020
Statut:
ppublish
Résumé
Prophylactic oxytocin administration at the third stage of labour reduces blood loss and the need for additional uterotonic drugs. Obesity is known to be associated with an increased risk of uterine atony and postpartum haemorrhage. It is unknown whether women with obesity require higher doses of oxytocin in order to achieve adequate uterine tone after delivery. The purpose of this study was to establish the bolus dose of oxytocin required to initiate effective uterine contraction in 90% of women with obesity (the ED
Substances chimiques
Oxytocics
0
Oxytocin
50-56-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
918-923Subventions
Organisme : Department of Anaesthesia
Organisme : University of Toronto
Informations de copyright
© 2020 Association of Anaesthetists.
Références
Kassebaum N, Barber R, Bhutta Z, et al. Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388: 1775-812.
Knight M, Bunch K, Tuffnell D, et al. (Eds.); on behalf of MBRRACE-UK. Saving Lives, Improving Mothers’ Care - Lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2014-16. Oxford: National Perinatal Epidemiology Unit, University of Oxford, 2018.
Calvert C, Thomas SL, Ronsmans C, Wagner KS, Adler AJ, Filippi V. Identifying regional variation in the prevalence of postpartum haemorrhage: a systematic review and meta-analysis. PLoS One 2012; 7: e41114.
Knight M, Callaghan W, Berg C, et al. Trends in postpartum haemorrhage in high resource countries: a review and recommendations from the International Postpartum Haemorrhage Collaborative Group. BMC Pregnancy and Childbirth 2009; 9: 55.
Kramer MS, Berg C, Abenhaim H, Dahhou M, Rouleu J, Mehrabadi A, Joseph K. Incidence, risk factors, and temporal trends in severe postpartum haemorrhage. American Journal of Obstetrics and Gynecology 2013; 209: 449. e1-7.
Mehrabadi A, Hutcheon J, Lee L, Kramer M, Liston R, Joseph K. Epidemiological investigation of a temporal increase in atonic postpartum haemorrhage: a population-based retrospective cohort study. British Journal of Obstetrics and Gynaecology 2013; 120: 853-62.
Salati JA, Leathersich SJ, Williams MJ, Cuthbert A, Tolosa JE. Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage. Cochrane Database of Systematic Reviews 2019; 4: CD001808.
Butwick AJ, Coleman L, Cohen SE, Riley ET, Carvalho B. Minimum effective bolus dose of oxytocin during elective Caesarean delivery. British Journal of Anaesthesia 2010; 104: 338-43.
Pinder AJ, Dresner M, Calow C, Shorten GD, O’Riordan J, Johnson R. Haemodynamic changes caused by oxytocin during caesarean section under spinal anaesthesia. International Journal of Obstetric Anesthesia 2002; 11: 156-9.
Thomas J, Koh S, Cooper G. Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing Caesarean section. British Journal of Anaesthesia 2007; 98: 116-9.
Heslehurst N, Ells LJ, Simpson H, Batterham A, Wilkinson J, Summerbell CD. Trends in maternal obesity incidence rates, demographic predictors, and health inequalities in 36,821 women over a 15-year period. British Journal of Obstetrics and Gynaecology 2007; 114: 187-94.
Ma R, Schmidt M, Tam W, McIntyre H, Catalano P. Clinical management of pregnancy in the obese mother: before conception, during pregnancy, and postpartum. Lancet Diabetes and Endocrinology 2016; 4: 1037-49.
Poston L, Caleyachetty R, Cnattingius S, Corvalan C, Uauy R, Herring S, Gillman M. Preconceptional and maternal obesity: epidemiology and health consequences. Lancet Diabetes and Endocrinology 2016; 4: 1025-36.
Blomberg M. Maternal obesity and risk of postpartum hemorrhage. Obstetrics and Gynecology 2011; 118: 561-8.
Butwick A, Abreo A, Bateman B, Lee H, El-Sayed Y, Stephansson O, Flood P. Effect of maternal body mass index on postpartum hemorrhage. Anesthesiology 2018; 128: 774-83.
Heslehurst N, Simpson H, Ells L, et al. The impact of maternal BMI status on pregnancy outcomes with immediate short-term obstetric resource implications: a meta-analysis. Obesity Reviews 2008; 9: 635-83.
Oteng-Ntim E, Kopeika J, Seed P, Wandiembe S, Doyle P. Impact of obesity on pregnancy outcome in different ethnic groups: calculating population attributable fractions. PLoS One 2013; 8: e53749.
Zhang J, Bricker L, Wray S, Quenby S. Poor uterine contractility in obese women. British Journal of Obstetrics and Gynaecology 2007; 114: 343-8.
Luca A, Carvalho JCA, Ramachandran N, Balki M. The effect of morbid obesity or advanced maternal age on oxytocin-induced myometrial contractions: an in vitro study. Canadian Journal of Anesthesia 2020; 67: 836-46.
Carvalho JCA, Balki M, Kingdom J, Windrim R. Oxytocin requirements at elective caesarean delivery: a dose-finding study. Obstetrics and Gynecology 2004; 104: 1005-10.
Sartain J, Barry J, Howat P, McCormack D, Bryant M. Intravenous oxytocin bolus of 2 units is superior to 5 units during elective Caesarean section. British Journal of Anaesthesia 2008; 101: 822-6.
Drew T, Balki M, Farine D, Ye XY, Downey K, Carvalho JCA. Carbetocin at elective caesarean section: a sequential allocation trial to determine the minimum effective dose in obese women. Anaesthesia 2020; 75: 1-7.
Mavrides E, Allard S, Chandraharan E,. et al. on behalf of the Royal College of Obstetricians and Gynaecologists. Prevention and management of postpartum haemorrhage. British Journal of Obstetrics and Gynaecology 2016; 124: e106-e149.
Magee LA, Pels A, Helewa M, et al. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary. Journal of Obstetrics and Gynaecology Canada 2014; 36: 416-38.
Vricella L, Louis J, Chien E, Mercer B. Blood volume determination in obese and normal-weight gravidas: the hydroxyethyl starch method. American Journal of Obstetrics and Gynecology 2015; 213: 408e1-6.
Pace NL, Stylianou MP. Advances in and limitations of up-and-down methodology: a precis of clinical use, study design, and dose estimation in anesthesia research. Anesthesiology 2007; 107: 144-52.
Stylianou M, Flournoy N. Dose finding using the biased coin up-and-down design and isotonic regression. Biometrics 2002; 58: 171-7.
Dixon WJ, Mood AM. A method for obtaining and analyzing sensitivity data. Journal of the American Statistical Association 1948; 43: 109-26.
Postpartum hemorrhage. Practice Bulletin No. 183. American College of Obstetricians and Gynecologists. Obstetrics and Gynecology 2017; 130: e168-86.
WHO recommendations: uterotonics for the prevention of postpartum haemorrhage. Geneva: World Health Organization; 2018.
Heesen M, Carvalho B, Carvalho JCA, et al. International consensus statement on the use of uterotonic agents during caesarean section. Anaesthesia 2019; 74: 1305-19.
Lisonkova S, Muraca G, Potts J, Liauw J, Chan W-S, Skoll A, Lim K. Association between prepregnancy body mass index and severe maternal morbidity. Journal of the American Medical Association 2017; 318: 1777-86.
Ovesen P, Ramussen S, Kesmodel U. Effect of prepregnancy maternal overweight and obesity on pregnancy outcome. Obstetrics and Gynecology 2011; 118: 305-12.
Schummers L, Hutcheon J, Bodnar L, Lieberman E, Himes K. Risk of adverse pregnancy outcomes by prepregnancy body mass index: a population-based study to inform prepregnancy weight loss counselling. Obstetrics and Gynecology 2015; 125: 133-43.
Gam C, Larson L, Mortensen O, et al. Unchanged mitochondrial phenotype, but accumulation of lipids in the myometrium in obese pregnant women. Journal of Physiology 2017; 23: 7109-22.
Hehir M, Morrison J. The adipokine apelin and human uterine contractility. American Journal of Obstetrics and Gynecology 2012; 206: 359.e1-359.e5.
Moynihan A, Hehir M, Glavey S, Smith T, Morrison J. Inhibitory effect of leptin on human uterine contractility in vitro. American Journal of Obstetrics and Gynecology 2006; 195: 504-9.
Adams A, Drassinower D. Are higher doses of oxytocin needed for obese women to achieve vaginal delivery? American Journal of Obstetrics and Gynecology 2018; 218(Suppl): S95.
Carlson N, Corwin E, Lowe N. Oxytocin augmentation in spontaneously laboring, nulliparous women: multilevel assessment of maternal BMI and oxytocin dose. Biological Research for Nursing 2017; 19: 382-92.
Hill M, Reed K, Cohen W. Oxytocin utilization for labor induction in obese and lean women. Journal of Perinatal Medicine 2015; 43: 703-6.
Maxwell C, Gaudet L, Cassir G, Nowik C, McLeod N, Jacob C, Walker M. Guideline no. 392-pregnancy and maternal obesity part 2: team planning for delivery and postpartum care. Journal of Obstetrics and Gynaecology Canada 2019; 41: 1660-75.
Cedergren MI. Non-elective caesarean delivery due to ineffective uterine contractility or due to obstructed labour in relation to maternal body mass index. European Journal of Obstetrics & Gynecology and Reproductive Biology 2009; 145: 163-6.
Chauhan S, Grobman W, Gherman R, Chauhan V, Chang G, Magann E, Hendrix N. Suspicion and treatment of the macrosomic fetus: A review. American Journal of Obstetrics and Gynecology 2005; 193: 332-46.