Tutorial: Chemistry of Hydrogen/Deuterium Exchange Mass Spectrometry.
Amides
/ chemistry
Deuterium Exchange Measurement
/ methods
Guanidine
/ chemistry
Hydrogen Deuterium Exchange-Mass Spectrometry
/ methods
Hydrogen-Ion Concentration
Hydroxides
/ chemistry
Imidazoles
/ chemistry
Indoles
/ chemistry
Models, Chemical
Phenols
/ chemistry
Proteins
/ chemistry
Protons
Solvents
/ chemistry
Temperature
backbone amide
hydrogen/deuterium exchange
mass spectrometry
proton transfer theory
reaction mechanism
Journal
Journal of the American Society for Mass Spectrometry
ISSN: 1879-1123
Titre abrégé: J Am Soc Mass Spectrom
Pays: United States
ID NLM: 9010412
Informations de publication
Date de publication:
06 Jan 2021
06 Jan 2021
Historique:
pubmed:
24
11
2020
medline:
2
10
2021
entrez:
23
11
2020
Statut:
ppublish
Résumé
Chemistry related to hydrogen/deuterium exchange-mass spectrometry (HDX-MS) for the analysis of proteins is described. First, the HDX rates of various functional groups in proteins are explained by reviewing the observed rates described in the literature, followed by estimating rates of all types of heteroatom hydrogens in proteins using proton transfer theory and the p
Identifiants
pubmed: 33227208
doi: 10.1021/jasms.0c00260
doi:
Substances chimiques
Amides
0
Hydroxides
0
Imidazoles
0
Indoles
0
Phenols
0
Proteins
0
Protons
0
Solvents
0
imidazole
7GBN705NH1
hydroxide ion
9159UV381P
Guanidine
JU58VJ6Y3B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM