Skin Cancer Development in Solid Organ Transplant Recipients in Switzerland (Swiss Transplant Cohort Study).
Adult
Aged
Carcinoma, Basal Cell
/ epidemiology
Carcinoma, Squamous Cell
/ epidemiology
Cohort Studies
Databases, Factual
Female
Humans
Immunosuppressive Agents
/ therapeutic use
Incidence
Male
Melanoma
/ epidemiology
Middle Aged
Organ Transplantation
Risk Factors
Skin Neoplasms
/ epidemiology
Switzerland
Basal cell carcinoma
Keratinocyte carcinoma
Melanoma
Organ transplant recipient
Organ transplantation
Skin cancer
Squamous cell carcinoma
Journal
Dermatology (Basel, Switzerland)
ISSN: 1421-9832
Titre abrégé: Dermatology
Pays: Switzerland
ID NLM: 9203244
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
03
2020
accepted:
27
05
2020
pubmed:
24
11
2020
medline:
16
2
2022
entrez:
23
11
2020
Statut:
ppublish
Résumé
Skin cancer, in particular squamous cell carcinoma, is the most frequent malignancy among solid organ transplant recipients with a higher incidence compared to the general population. To determine the skin cancer incidence in organ transplant recipients in Switzerland and to assess the impact of immunosuppressants and other risk factors. Prospective cohort study of solid organ transplant recipients in Switzerland enrolled in the Swiss Transplant Cohort Study from 2008 to 2013. 2,192 solid organ transplant recipients. Occurrence of first and subsequent squamous cell carcinoma, basal cell carcinoma, melanoma and other skin cancers after transplantation extracted from the Swiss Transplant Cohort Study database and validated by medical record review. Incidence rates were calculated for skin cancer overall and subgroups. The effect of risk factors on the occurrence of first skin cancer and recurrent skin cancer was calculated by the Cox proportional hazard model. In 2,192 organ transplant recipients, 136 (6.2%) developed 335 cases of skin cancer during a median follow-up of 32.4 months, with squamous cell carcinoma as the most frequent one. 79.4% of skin cancer patients were male. Risk factors for first and recurrent skin cancer were age at transplantation, male sex, skin cancer before transplantation and previous transplantation. For a first skin cancer, the number of immunosuppressive drugs was a risk factor as well. Skin cancer following solid organ transplantation in Switzerland is greatly increased with risk factors: age at transplantation, male sex, skin cancer before transplantation, previous transplantation and number of immunosuppressive drugs.
Identifiants
pubmed: 33227788
pii: 000510685
doi: 10.1159/000510685
pmc: PMC8619732
doi:
Substances chimiques
Immunosuppressive Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
970-980Informations de copyright
© 2020 The Author(s) Published by S. Karger AG, Basel.
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