Brain changes in NF-κB1 and epidermal growth factor system markers at peri-pubescence in the spiny mouse following maternal immune activation.
Animals
Behavior, Animal
/ physiology
Biomarkers
/ blood
Brain
/ metabolism
Disease Models, Animal
Epidermal Growth Factor
/ blood
Female
Genes, erbB-1
Hippocampus
/ metabolism
Mice
Motor Activity
/ drug effects
NF-kappa B
/ blood
Neurites
/ metabolism
Pregnancy
Prenatal Exposure Delayed Effects
/ immunology
Schizophrenia
/ etiology
Signal Transduction
ErbB1/EGFR
NF-κB1
Schizophrenia
Journal
Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
09
06
2020
accepted:
05
11
2020
pubmed:
25
11
2020
medline:
22
6
2021
entrez:
24
11
2020
Statut:
ppublish
Résumé
Environmental risk factors that operate at foetal or neonatal levels increase the vulnerability to schizophrenia, plausibly via stress-immune activation that perturbs the epidermal growth factor (EGF) system, a system critical for neurodevelopment. We investigated potential associations between environmental insults and immune and EGF system changes through a maternal immune activation (MIA) model, using the precocial spiny mice (Acomys cahirinus). After mid-gestation MIA prepubescent offspring showed elevated NF-κB1 protein in nucleus accumbens, decreased EGFR in caudate putamen and a trend for increased PI3K-110δ in ventral hippocampus. Thus, prenatal stress may cause a heightened NF-κB1-mediated immune attenuation of EGF system signalling.
Identifiants
pubmed: 33229121
pii: S0165-1781(20)33225-X
doi: 10.1016/j.psychres.2020.113564
pii:
doi:
Substances chimiques
Biomarkers
0
NF-kappa B
0
Epidermal Growth Factor
62229-50-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113564Informations de copyright
Copyright © 2020. Published by Elsevier B.V.