ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
Activating Transcription Factor 4
/ genetics
Adenosine Triphosphatases
/ genetics
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
/ genetics
Eflornithine
/ pharmacology
Fibroblasts
/ drug effects
Lysosomes
/ genetics
Mitochondria
/ drug effects
Mutation
/ genetics
Oxidative Stress
/ drug effects
Parkinson Disease
/ genetics
Polyamines
/ metabolism
Proton-Translocating ATPases
/ genetics
Rotenone
/ pharmacology
Spermine
/ metabolism
Transcription Factor CHOP
/ genetics
Transcription Factors
/ genetics
P5B-type ATPase
antioxidant
mitochondria
neurodegeneration
polyamine transport
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
08 12 2020
08 12 2020
Historique:
pubmed:
25
11
2020
medline:
30
1
2021
entrez:
24
11
2020
Statut:
ppublish
Résumé
Recessive loss-of-function mutations in
Identifiants
pubmed: 33229544
pii: 1922342117
doi: 10.1073/pnas.1922342117
pmc: PMC7733819
doi:
Substances chimiques
ATF4 protein, human
0
ATFS-1 protein, C elegans
0
ATP13A2 protein, human
0
Caenorhabditis elegans Proteins
0
DDIT3 protein, human
0
Polyamines
0
Transcription Factors
0
Rotenone
03L9OT429T
Activating Transcription Factor 4
145891-90-3
Transcription Factor CHOP
147336-12-7
Spermine
2FZ7Y3VOQX
Adenosine Triphosphatases
EC 3.6.1.-
CATP-6 protein, C elegans
EC 3.6.1.-
Proton-Translocating ATPases
EC 3.6.3.14
Eflornithine
ZQN1G5V6SR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
31198-31207Subventions
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: Patent WO-2018002350-A1 of KU Leuven describes methods for detecting compounds with therapeutic use that target ATP13A2 or related isoforms using biological material and assays described in the current manuscript. A second patent of KU Leuven describing ATP13A2 cell models described in this manuscript has also been filed.
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