Analysis of sweating by optical coherence tomography in patients with palmoplantar hyperhidrosis.
hyperhidrosis
optical coherence tomography
palmoplantar
ventilated-capsule method
Journal
The Journal of dermatology
ISSN: 1346-8138
Titre abrégé: J Dermatol
Pays: England
ID NLM: 7600545
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
17
07
2020
accepted:
19
10
2020
pubmed:
25
11
2020
medline:
15
5
2021
entrez:
24
11
2020
Statut:
ppublish
Résumé
Optical coherence tomography (OCT) is a high-resolution tomographic imaging technique that uses optical interference. OCT has enabled the non-invasive three-dimensional analysis of individual acrosyringia in the stratum corneum in human skin. However, no report on the measurement of sweating by OCT using clinical data from humans has been published to date. Twenty patients with hyperhidrosis and twenty healthy subjects were included in this study. Imaging of acrosyringia in the stratum corneum using OCT and measurement of the sweat rate using the ventilated capsule method were performed simultaneously. The hand grip exercise of the right hand was used as a load to induce sweating, and the left fingertip was measured before and after the exercise load. Five acrosyringia were extracted from each OCT image, and their volumes were calculated. The mean volume of each acrosyringium was divided by the thickness of the stratum corneum to calculate the mean cross-sectional area of the acrosyringium. Furthermore, the number of sweat droplets on the skin surface was measured. The mean cross-sectional area of acrosyringia after the load increased both in patients with hyperhidrosis and in healthy subjects (P < 0.001). The mean cross-sectional area of acrosyringia of patients with hyperhidrosis was larger than that of healthy subjects (P < 0.001). The mean cross-sectional area of acrosyringia and the sweat rate showed a positive correlation before and after the load (r = 0.88 to 0.91). The number of droplets also increased after the load (P < 0.001), and the number of droplets in patients with hyperhidrosis was higher than in healthy subjects (P < 0.001). Our study has shown that acrosyringia in the stratum corneum increase in proportion to the sweat rate. OCT is a rigorous and valuable method that can measure and quantify sweating in the body without being an invasive procedure.
Identifiants
pubmed: 33230876
doi: 10.1111/1346-8138.15694
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
334-343Subventions
Organisme : Ministry of Health, Labor and Welfare
ID : 19FC0201
Informations de copyright
© 2020 Japanese Dermatological Association.
Références
Hornberger J, Grimes K, Naumann M et al. Recognition, diagnosis, and treatment of primary focal hyperhidrosis. J Am Acad Dermatol 2004; 51: 274-286.
Nawrocki S, Cha J. The etiology, diagnosis, and management of hyperhidrosis: a comprehensive review: etiology and clinical work-up. J Am Acad Dermatol 2019; 81: 657-666.
Fujimoto T, Kawahara K, Yokozeki H et al. Epidemiological study and considerations of primary focal hyperhidrosis in Japan: from questionnaire analysis. J Dermatol 2013; 40: 886-890.
Doolittle J, Walker P, Mills T et al. Hyperhidrosis: an update on prevalence and severity in the United States. Ach Dermatol Res 2016; 308: 743-749.
Kouris A, Armyra K, Christodoulou C et al. Quality of life in patients with focal hyperhidrosis before and after treatment with botulinum toxin A. ISRN Dermatol 2014; 1-4.
Shayesteh A, Janlert U, Nylander E et al. Hyperhidrosis-sweating sites matter: quality of life in primary hyperhidrosis according to the sweating sites measured by SF-36. Dermatology 2017; 233: 441-445.
Walling HW. Primary hyperhidrosis increases the risk of cutaneous infection: a case-control study of 387 patients. J Am Acad Dermatol 2009; 61: 242-246.
Albert RE, Palmes ED. Evaporative rate patterns from small skin areas as measured by an infrared gas analyzer. J Appl Physiol 1951; 4: 208-214.
Taylor NAS, Machado-Moreira CA. Regional variations in transepidermal water loss, eccrine sweat gland density, sweat secretion rates and electrolyte composition in resting and exercising humans. Extrem Physiol Med 2013; 2: 1-29.
Yokozeki H, Katayama I, Nishioka K et al. The role of metal allergy and local hyperhidrosis in the pathogenesis of pompholyx. J Dermatol 1992; 19: 964-67.
Ohhashi T, Sakaguchi M, Tsuda T. Human perspiration measurement. Physiol Meas 1998; 19: 449-461.
Huang D, Swanson EA, Lin CP et al. Optical coherence tomography. Science 1991; 254: 1178-1181.
Aumann S, Donner S, Fischer J et al. Optical coherence tomography (OCT): principle and technical realization. In: Bille JF, ed. High Resolution Imaging in Microscopy and Ophthalmology. Cham: Springer, 2019; 59-85.
Welzel J, Lankenau E, Birngruber R et al. Optical coherence tomography of the human skin. J Am Acad Dermatol 1997; 37: 958-963.
Mrejen S, Spaide RF. Optical coherence tomography: imaging of the choroid and beyond. Surv Opthalmol 2013; 58: 387-429.
Prati F, Regar E, Mintz GS et al. Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis. Eur Heart J 2010; 31: 401-415.
Hsiung PL, Pantanowitz L, Aguirre AD et al. Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines. Gastrointest Endosc 2005; 62: 561-574.
Oh BH, Kim KH, Chung KY. Skin imaging using ultrasound imaging, optical coherence tomography, confocal microscopy, and two-photon microscopy in cutaneous oncology. Front Med 2019; 6: e274.
Nishizawa A. Dyshidrotic eczema and its relationship to metal allergy. Curr Probl Dermatol 2016; 51: 80-85.
Tey HL, Tay EY, Cao T. In vivo imaging of Miliaria profunda using high-definition optical coherence tomography: diagnosis, pathogenesis, and treatment. JAMA Dermatol 2015; 151: 346-348.
Gambichler T, Moussa G, Sand M et al. Applications of optical coherence tomography in dermatology. J Dermatol Sci 2005; 40: 85-94.
Ohmi M, Nohara K, Ueda Y et al. Dynamic observation of sweat glands of human finger tip using all-optical-fiber high-speed optical coherence tomography. Jpn J Appl Phys 2005; 44: 24-27.
Sugawa Y, Fukuda A, Ohmi M. Precise measurement of volume of eccrine sweat gland in mental sweating by optical coherence tomography. Opt Rev 2015; 22: 359-364.
Ohmi M, Tanigawa M, Yamada A, Ueda Y, Haruna M. Dynamic analysis of internal and external mental sweating by optical coherence tomography. J Biomed Optics 2009; 14: 01402.
Ohmi M, Tanigawa M, Wada Y et al. Dynamic analysis for mental sweating of a group of eccrine sweat glands on a human fingertip by optical coherence tomography. Skin Res Technol 2012; 18: 378-383.
Ohmi M, Wada Y. Dynamic analysis of mental sweating of eccrine sweat gland of human fingertip by time-sequential piled-up en face optical coherence tomography images. Conf Proc IEEE Eng Med Biol Soc 2016; 3918-3921.
Tomioka N, Kobayashi M, Ushiyama Y et al. Effects of exercise intensity, posture, pressure on the back and ambient temperature on palmar sweating responses due to handgrip exercises in humans. Auton Neurosci 2005; 118: 125-134.
Amano T, Kai S, Nakajima M et al. Sweating responses to isometric hand-grip exercise and forearm muscle metaboreflex in prepubertal children and elderly. Exp Physiol 2017; 102: 214-227.
Fruhstorfer H, Abel U, Garthe CD, Knüttel A. Thickness of the stratum corneum of the volar fingertips. Clin Anat 2000; 13: 429-433.
Sato K, Kang WH, Saga K et al. Biology of sweat glands and their disorders. II. Disorders of sweat gland function. J Am Acad Dermatol 1989; 20: 713-726.
Bovell DL, Clunes MT, Elder HY et al. Ultrastructure of the hyperhidrotic eccrine sweat gland. Br J Dermatol 2001; 145: 298-301.
Yanagishita T, Tamada Y, Ohshima Y et al. Histological localization of aluminum in topical aluminum chloride treatment for palmar hyperhidrosis. J Dermatol Sci 2012; 67: 69-71.
Matsui S, Murota H, Takahashi A et al. Dynamic analysis of histamine-mediated attenuation of acetylcholine-induced sweating via GSK3β activation. J Invest Dermatol 2014; 134: 326-334.