Inhibitory Effect of Lithospermic Acid on the HIV-1 Nucleocapsid Protein.
Anti-HIV Agents
/ chemistry
Benzofurans
/ chemistry
Biological Products
/ chemistry
Depsides
/ chemistry
Dose-Response Relationship, Drug
Drug Stability
HIV Infections
/ drug therapy
HIV-1
/ drug effects
Humans
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
Nucleocapsid Proteins
/ antagonists & inhibitors
Protein Binding
Structure-Activity Relationship
HIV
catechol
fluorescence-based assays
lithospermic acid
molecular modeling
natural products
nucleocapsid protein
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
20 Nov 2020
20 Nov 2020
Historique:
received:
28
09
2020
revised:
10
11
2020
accepted:
18
11
2020
entrez:
25
11
2020
pubmed:
26
11
2020
medline:
10
4
2021
Statut:
epublish
Résumé
The HIV-1 nucleocapsid protein (NC) is a desirable target in antiretroviral therapy due to its high conservation among HIV-1 strains, and to its multiple and crucial roles in the HIV-1 replication cycle. Natural products represent a valuable source of NC inhibitors, with the catechol group being a privileged scaffold in NC inhibition. By coupling molecular modeling with NMR spectroscopy and fluorescence-based assays, we disclosed lithospermic acid, a catechol derivative extracted from
Identifiants
pubmed: 33233563
pii: molecules25225434
doi: 10.3390/molecules25225434
pmc: PMC7699738
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Benzofurans
0
Biological Products
0
Depsides
0
Nucleocapsid Proteins
0
lithospermic acid
100IP83JAC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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