Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1.
Journal
Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400
Informations de publication
Date de publication:
24 11 2020
24 11 2020
Historique:
entrez:
25
11
2020
pubmed:
26
11
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Human coronavirus HKU1 (HCoV-HKU1) is associated with respiratory disease and is prevalent worldwide, but an in vitro model for viral replication is lacking. An interaction between the coronaviral spike (S) protein and its receptor is the primary determinant of tissue and host specificity; however, viral entry is a complex process requiring the concerted action of multiple cellular elements. Here, we found that the protease kallikrein 13 (KLK13) was required for the infection of human respiratory epithelial cells and was sufficient to mediate the entry of HCoV-HKU1 into nonpermissive RD cells. We also demonstrated the cleavage of the HCoV-HKU1 S protein by KLK13 in the S1/S2 region, suggesting that KLK13 is the priming enzyme for this virus. Together, these data suggest that protease distribution and specificity determine the tissue and cell specificity of the virus and may also regulate interspecies transmission.
Identifiants
pubmed: 33234691
pii: 13/659/eaba9902
doi: 10.1126/scisignal.aba9902
pmc: PMC7857416
pii:
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
KLK13 protein, human
EC 3.4.21.-
Kallikreins
EC 3.4.21.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Références
J Virol. 2015 Jul;89(14):7202-13
pubmed: 25926653
J Gen Virol. 2014 Apr;95(Pt 4):836-848
pubmed: 24394697
J Virol. 2008 Sep;82(17):8887-90
pubmed: 18562523
Biol Chem. 2006 Jun;387(6):653-63
pubmed: 16800726
J Virol. 2019 Sep 12;93(19):
pubmed: 31315999
Pharmacol Res Perspect. 2015 Mar;3(2):e00119
pubmed: 26038695
J Virol. 2008 Jun;82(12):6078-83
pubmed: 18400867
J Virol. 2013 Jul;87(14):7790-2
pubmed: 23678167
Contemp Oncol (Pozn). 2014;18(4):246-51
pubmed: 25258582
J Biol Chem. 2013 Jun 14;288(24):17399-407
pubmed: 23612974
Biochem Biophys Res Commun. 2013 Apr 12;433(3):333-7
pubmed: 23500465
J Virol. 2018 Sep 12;92(19):
pubmed: 30021905
J Med Genet. 2004 Jul;41(7):545-9
pubmed: 15235027
J Virol. 2007 Aug;81(16):8722-9
pubmed: 17522231
Viruses. 2019 Apr 05;11(4):
pubmed: 30959796
J Invest Dermatol. 2010 May;130(5):1297-306
pubmed: 20090765
Anticancer Res. 2015 Apr;35(4):1861-6
pubmed: 25862839
Breast Cancer Res Treat. 2000 Feb;59(3):263-70
pubmed: 10832596
J Virol. 2018 Jan 17;92(3):
pubmed: 29142129
N Engl J Med. 2012 Nov 8;367(19):1814-20
pubmed: 23075143
Mol Oncol. 2007 Dec;1(3):269-87
pubmed: 19383303
Nature. 2003 Nov 27;426(6965):450-4
pubmed: 14647384
Clin Chem. 2003 Jan;49(1):77-86
pubmed: 12507963
Elife. 2020 Jul 07;9:
pubmed: 32633718
PLoS One. 2016 Jun 01;11(6):e0156552
pubmed: 27249425
J Gen Virol. 2012 Sep;93(Pt 9):1924-1929
pubmed: 22718567
PLoS Med. 2005 Aug;2(8):e240
pubmed: 16104827
Proc Natl Acad Sci U S A. 2005 May 31;102(22):7988-93
pubmed: 15897467
Biochimie. 2016 Mar;122:270-82
pubmed: 26408415
Clin Chem. 2007 Aug;53(8):1423-32
pubmed: 17573418
J Virol. 2015 Jul;89(14):7038-52
pubmed: 25926655
Cell Host Microbe. 2017 Mar 8;21(3):356-366
pubmed: 28279346
Antiviral Res. 2013 Feb;97(2):112-21
pubmed: 23201315
J Virol. 2013 Jun;87(11):6150-60
pubmed: 23536651
Biol Chem. 2007 Apr;388(4):427-35
pubmed: 17391064
Nature. 2016 Mar 3;531(7592):118-21
pubmed: 26935699
J Virol. 2006 Jun;80(12):5768-76
pubmed: 16731916
Nature. 2013 Mar 14;495(7440):251-4
pubmed: 23486063
Biol Chem. 2006 Jun;387(6):733-40
pubmed: 16800734
Elife. 2020 Apr 27;9:
pubmed: 32338605
J Virol. 2011 May;85(9):4122-34
pubmed: 21325420
Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81
pubmed: 16081529
J Med Virol. 2009 Sep;81(9):1597-604
pubmed: 19626607
Cell. 2006 Mar 24;124(6):1283-98
pubmed: 16564017
J Virol. 2013 Jun;87(11):6081-90
pubmed: 23427150
ISRN Dent. 2013 Sep 16;2013:684607
pubmed: 24159389
Biol Chem. 2008 Jun;389(6):643-51
pubmed: 18627296
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2681-2690
pubmed: 30679277
Innate Immun. 2015 Aug;21(6):575-86
pubmed: 25563717
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4526-9
pubmed: 3380803
Psychiatry Clin Neurosci. 2000 Aug;54(4):419-26
pubmed: 10997858
Antiviral Res. 2015 Apr;116:76-84
pubmed: 25666761
PLoS One. 2018 Sep 5;13(9):e0203489
pubmed: 30183777
Cell Res. 2008 Feb;18(2):290-301
pubmed: 18227861
J Virol. 2009 Jan;83(2):712-21
pubmed: 18971274
J Gen Virol. 2008 Sep;89(Pt 9):2147-2156
pubmed: 18753224
J Biol Chem. 2006 Oct 27;281(43):32095-112
pubmed: 16885167
Biochimie. 2011 Oct;93(10):1701-9
pubmed: 21689719
PLoS Pathog. 2017 Jul 31;13(7):e1006546
pubmed: 28759649
PLoS One. 2009 Nov 17;4(11):e7870
pubmed: 19924243
PLoS One. 2013 Nov 20;8(11):e82267
pubmed: 24278477
J Virol. 2009 Sep;83(17):8744-58
pubmed: 19553314
J Virol. 2010 Nov;84(21):11255-63
pubmed: 20719951
J Virol. 2013 Dec;87(23):12552-61
pubmed: 24027332
Acta Derm Venereol. 1991;71(6):471-4
pubmed: 1685827
J Virol. 2004 Jun;78(11):6048-54
pubmed: 15141003
Sci Rep. 2018 May 8;8(1):7124
pubmed: 29740099
Lab Invest. 2005 Jan;85(1):75-89
pubmed: 15531908
Nat Commun. 2017 May 23;8:15216
pubmed: 28534504
Nat Med. 2004 Apr;10(4):368-73
pubmed: 15034574
J Virol. 2005 Jan;79(2):884-95
pubmed: 15613317
J Virol. 1991 Apr;65(4):1916-28
pubmed: 1848311
J Biol Chem. 2016 Nov 18;291(47):24779-24786
pubmed: 27729455
J Virol. 2017 Jul 27;91(16):
pubmed: 28615200
Cell Mol Life Sci. 2008 Jan;65(2):237-52
pubmed: 17965832
J Biol Chem. 2000 Dec 1;275(48):37397-406
pubmed: 10969073
J Invest Dermatol. 2000 Jan;114(1):56-63
pubmed: 10620116
Biol Chem. 2001 Jan;382(1):5-14
pubmed: 11258672
J Biol Chem. 2010 Oct 15;285(42):32174-81
pubmed: 20667819
J Virol. 2014 Nov;88(22):13221-30
pubmed: 25187545
Adv Exp Med Biol. 2006;581:281-4
pubmed: 17037543
Virology. 2018 Apr;517:9-15
pubmed: 29217279
Adv Exp Med Biol. 2006;581:219-27
pubmed: 17037533
Viruses. 2012 Apr;4(4):557-80
pubmed: 22590686
N Engl J Med. 2003 Dec 18;349(25):2431-41
pubmed: 14681510
Int J Mol Sci. 2019 Mar 28;20(7):
pubmed: 30925705
J Biol Chem. 2009 Nov 27;284(48):32989-94
pubmed: 19819870
J Virol. 2004 Aug;78(16):8701-8
pubmed: 15280478
Endocr Rev. 2010 Aug;31(4):407-46
pubmed: 20103546
Am J Respir Cell Mol Biol. 2013 Sep;49(3):341-7
pubmed: 23713995
Int J Biol Markers. 2006 Apr-Jun;21(2):106-10
pubmed: 16847813
Arch Virol. 2011 Oct;156(10):1749-56
pubmed: 21667287
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15214-9
pubmed: 25288733
PLoS One. 2013 Jul 24;8(7):e70129
pubmed: 23894604
BMC Infect Dis. 2013 Sep 16;13:433
pubmed: 24040960
J Clin Oncol. 2004 Feb 15;22(4):678-85
pubmed: 14966091
Virology. 2011 May 10;413(2):265-74
pubmed: 21435673
J Virol. 2013 May;87(10):5502-11
pubmed: 23468491
Mol Cell. 2019 Feb 21;73(4):830-844.e12
pubmed: 30639242
Peptides. 2011 Jun;32(6):1187-92
pubmed: 21439340
Front Immunol. 2018 Feb 02;9:156
pubmed: 29456540
Nature. 1992 Jun 4;357(6377):420-2
pubmed: 1350662
J Virol. 2011 Aug;85(15):7872-80
pubmed: 21613395
Biol Chem. 2006 Jun;387(6):817-24
pubmed: 16800746