Adam Lesner

Affiliations

Faculty of Chemistry, University of Gdansk, 80-308 Gdansk, Poland.

Publications (38)

Activity-based protein profiling guided identification of urine proteinase 3 activity in subclinical rejection after renal transplantation.

Clinical proteomics

Avec: Mario Navarrete , Brice Korkmaz , Carla Guarino , Adam Lesner , Ying Lao , Julie Ho , Peter Nickerson , John A Wilkins

Elastolytic activity is associated with inflammation in bladder cancer.

Journal of biochemistry

Avec: Natalia Gruba , Lech Stachurski , Adam Lesner

Bile Acids: Key Players in Inflammatory Bowel Diseases?

Cells

Avec: Aicha Kriaa , Vincent Mariaule , Amin Jablaoui , Soufien Rhimi , Hela Mkaouar , Juan Hernandez , Brice Korkmaz , Adam Lesner , Emmanuelle Maguin , Ali Aghdassi , Moez Rhimi

Theoretical Investigation of the Coronavirus SARS-CoV-2 (COVID-19) Infection Mechanism and Selectivity.

Molecules (Basel, Switzerland)

Avec: Iga Biskupek , Adam Sieradzan , Cezary Czaplewski , Adam Liwo , Adam Lesner , Artur Giełdoń

Novel tools to study West Nile virus NS3 protease activity.

Bioorganic chemistry

Avec: Joanna Pianka , Natalia Gruba , Adam Lesner

Initial study of the detection of ADAM 10 in the urine of type-2 diabetic patients.

Bioorganic chemistry

Avec: Natalia Gruba , Agnieszka Piwkowska , Adam Lesner

ADAM10 as a major activator of reactive oxygen species production and klotho shedding in podocytes under diabetic conditions.

Biochemical pharmacology

Avec: Agnieszka Piwkowska , Patrycja Rachubik , Marlena Typiak , Tomasz Kulesza , Irena Audzeyenka , Moin A Saleem , Natalia Gruba , Magdalena Wysocka , Adam Lesner , Dorota Rogacka

Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia.

Biochimica et biophysica acta. Molecular cell research

Avec: Irena Audzeyenka , Patrycja Rachubik , Dorota Rogacka , Marlena Typiak , Tomasz Kulesza , Stefan Angielski , Michał Rychłowski , Magdalena Wysocka , Natalia Gruba , Adam Lesner , Moin A Saleem , Agnieszka Piwkowska

Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin.

The FEBS journal

Avec: Koffi N'Guessan , Renata Grzywa , Seda Seren , Guillaume Gabant , Maria A Juliano , Marc Moniatte , Alain van Dorsselaer , Joseph G Bieth , Christine Kellenberger , Francis Gauthier , Magdalena Wysocka , Adam Lesner , Marcin Sienczyk , Martine Cadene , Brice Korkmaz

Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Jonas Hahn , Christine Schauer , Christine Czegley , Lasse Kling , Lenka Petru , Benjamin Schmid , Daniela Weidner , Christiane Reinwald , Mona H C Biermann , Stefan Blunder , Jürgen Ernst , Adam Lesner , Tobias Bäuerle , Ralf Palmisano , Silke Christiansen , Martin Herrmann , Aline Bozec , Robert Gruber , Georg Schett , Markus H Hoffmann

Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C.

Biochemical pharmacology

Avec: Brice Korkmaz , Adam Lesner , Magdalena Wysocka , Artur Gieldon , Maria Håkansson , Francis Gauthier , Derek T Logan , Dieter E Jenne , Conni Lauritzen , John Pedersen

Electrochemical detection of bacterial endotoxin lipopolysaccharide (LPS) on gold electrode modified with DAL-PEG-DK5-PEG-OH - Antimicrobial peptide conjugate.

Talanta

Avec: Paulina Kosikowska-Adamus , Anna Golda , Jacek Ryl , Magdalena Pilarczyk-Zurek , Grzegorz Bereta , Tadeusz Ossowski , Adam Lesner , Joanna Koziel , Adam Prahl , Paweł Niedziałkowski

Serine proteases and metalloproteases are highly increased in irritable bowel syndrome Tunisian patients.

Scientific reports

Avec: Souha Soussou , Amin Jablaoui , Vincent Mariaule , Aicha Kriaa , Houda Boudaya , Magdalena Wysocka , Ali Amouri , Ali Gargouri , Adam Lesner , Emmanuelle Maguin , Moez Rhimi

Properties of the HtrA Protease From Bacterium

Frontiers in microbiology

Avec: Urszula Zarzecka , Anna Modrak-Wójcik , Donata Figaj , Malgorzata Apanowicz , Adam Lesner , Agnieszka Bzowska , Barbara Lipinska , Anna Zawilak-Pawlik , Steffen Backert , Joanna Skorko-Glonek

Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity.

International journal of molecular sciences

Avec: Natalia Gruba , Ewa Bielecka , Magdalena Wysocka , Anna Wojtysiak , Magdalena Brzezińska-Bodal , Kamila Sychowska , Magdalena Kalińska , Małgorzata Magoch , Aleksandra Pęcak , Katherine Falkowski , Magdalena Wiśniewska , Laura Sąsiadek , Karolina Płaza , Eileen Kroll , Anastasija Pejkovska , Maren Rehders , Klaudia Brix , Grzegorz Dubin , Tomasz Kantyka , Jan Potempa , Adam Lesner

Proteinase 3 phosphonic inhibitors.

Biochimie

Avec: Renata Grzywa , Adam Lesner , Brice Korkmaz , Marcin Sieńczyk

Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?

Journal of medicinal chemistry

Avec: Brice Korkmaz , Adam Lesner , Sylvain Marchand-Adam , Celia Moss , Dieter E Jenne

Analysis of urinary kallikrein-related peptidase 13 for monitoring bladder cancer.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Avec: Natalia Gruba , Patrycja Rachubik , Agnieszka Piwkowska , Adam Lesner

Novel Cell Permeable Polymers of

International journal of molecular sciences

Avec: Anita Romanowska , Katarzyna Węgrzyn , Katarzyna Bury , Emilia Sikorska , Aleksandra Gnatek , Agnieszka Piwkowska , Igor Konieczny , Adam Lesner , Magdalena Wysocka

Structural Determinants of Substrate Specificity of SplF Protease from

International journal of molecular sciences

Avec: Natalia Stach , Abdulkarim Karim , Przemyslaw Golik , Radoslaw Kitel , Katarzyna Pustelny , Natalia Gruba , Katarzyna Groborz , Urszula Jankowska , Sylwia Kedracka-Krok , Benedykt Wladyka , Marcin Drag , Adam Lesner , Grzegorz Dubin

Detection of ADAM15 in urine from patients with bladder cancer.

Analytical biochemistry

Avec: Natalia Gruba , Monika Musielak , Wiktoria Rejmak , Adam Lesner

Role of lysosomes in insulin signaling and glucose uptake in cultured rat podocytes.

Biochemical and biophysical research communications

Avec: Patrycja Rachubik , Dorota Rogacka , Irena Audzeyenka , Marlena Typiak , Magdalena Wysocka , Maria Szrejder , Adam Lesner , Agnieszka Piwkowska

Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1.

Science signaling

Avec: Aleksandra Milewska , Katherine Falkowski , Magdalena Kulczycka , Ewa Bielecka , Antonina Naskalska , Pawel Mak , Adam Lesner , Marek Ochman , Maciej Urlik , Elftherios Diamandis , Ioannis Prassas , Jan Potempa , Tomasz Kantyka , Krzysztof Pyrc

Non-Proteasomal Urine Activity in Bladder Cancer.

Chemistry & biodiversity

Avec: Natalia Gruba , Lech Stachurski , Adam Lesner

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis.

International journal of molecular sciences

Avec: Anne-Sophie Lamort , Yveline Hamon , Cezary Czaplewski , Artur Gieldon , Seda Seren , Laurent Coquet , Fabien Lecaille , Adam Lesner , Gilles Lalmanach , Francis Gauthier , Dieter Jenne , Brice Korkmaz

Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.

American journal of human genetics

Avec: Stefan Haskamp , Heiko Bruns , Madelaine Hahn , Markus Hoffmann , Anne Gregor , Sabine Löhr , Jonas Hahn , Christine Schauer , Mark Ringer , Cindy Flamann , Benjamin Frey , Adam Lesner , Christian T Thiel , Arif B Ekici , Stephan von Hörsten , Gunter Aßmann , Claudia Riepe , Maximilien Euler , Knut Schäkel , Sandra Philipp , Jörg C Prinz , Rotraut Mößner , Florina Kersting , Michael Sticherling , Abdelaziz Sefiani , Jaber Lyahyai , Wiebke Sondermann , Vinzenz Oji , Peter Schulz , Dagmar Wilsmann-Theis , Heinrich Sticht , Georg Schett , André Reis , Steffen Uebe , Silke Frey , Ulrike Hüffmeier

Lipidation of Temporin-1CEb Derivatives as a Tool for Activity Improvement, Pros and Cons of the Approach.

International journal of molecular sciences

Avec: Paulina Kosikowska-Adamus , Emilia Sikorska , Dariusz Wyrzykowski , Aleksandra Walewska , Anna Golda , Milena Deptuła , Michał Obuchowski , Adam Prahl , Michał Pikuła , Adam Lesner

Optimization of fluorescent substrates for ADAM17 and their utility in the detection of diabetes.

Analytical biochemistry

Avec: Honorata Sikora , Natalia Gruba , Magdalena Wysocka , Agnieszka Piwkowska , Adam Lesner

Caspase-like activity is associated with bacterial infection of the urine in urinary tract diseases.

Analytical biochemistry

Avec: Natalia Gruba , Honorata Sikora , Justyna Ciesielska , Wiktoria Rejmak , Adam Lesner

A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome.

International journal of molecular sciences

Avec: Magdalena Wysocka , Anita Romanowska , Natalia Gruba , Michalina Michalska , Artur Giełdoń , Adam Lesner

Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis.

International journal of molecular sciences

Avec: Katherine Falkowski , Ewa Bielecka , Ida B Thøgersen , Oliwia Bocheńska , Karolina Płaza , Magdalena Kalińska , Laura Sąsiadek , Małgorzata Magoch , Aleksandra Pęcak , Magdalena Wiśniewska , Natalia Gruba , Magdalena Wysocka , Anna Wojtysiak , Magdalena Brzezińska-Bodal , Kamila Sychowska , Anastasija Pejkovska , Maren Rehders , Georgina Butler , Christopher M Overall , Klaudia Brix , Grzegorz Dubin , Adam Lesner , Andrzej Kozik , Jan J Enghild , Jan Potempa , Tomasz Kantyka

Fecal Serine Protease Profiling in Inflammatory Bowel Diseases.

Frontiers in cellular and infection microbiology

Avec: Amin Jablaoui , Aicha Kriaa , Héla Mkaouar , Nizar Akermi , Souha Soussou , Magdalena Wysocka , Dominika Wołoszyn , Ali Amouri , Ali Gargouri , Emmanuelle Maguin , Adam Lesner , Moez Rhimi

The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer.

Molecular oncology

Avec: Thomas Kryza , Nathalie Bock , Scott Lovell , Anja Rockstroh , Melanie L Lehman , Adam Lesner , Janaththani Panchadsaram , Lakmali Munasinghage Silva , Srilakshmi Srinivasan , Cameron E Snell , Elizabeth D Williams , Ladan Fazli , Martin Gleave , Jyotsna Batra , Colleen Nelson , Edward W Tate , Jonathan Harris , John D Hooper , Judith A Clements

Simplified Theta-defensin [Ser

Anticancer research

Avec: Joanna Pianka , Natalia Gruba , Kamila Kitowska , Kamil Mieczkowski , Magdalena Wysocka , Rafał Sądej , Adam Lesner

SP-1, a Serine Protease from the Gut Microbiota, Influences Colitis and Drives Intestinal Dysbiosis in Mice.

Cells

Avec: Aicha Kriaa , Amin Jablaoui , Soufien Rhimi , Souha Soussou , Héla Mkaouar , Vincent Mariaule , Natalia Gruba , Ali Gargouri , Emmanuelle Maguin , Adam Lesner , Moez Rhimi

Digestive Inflammation: Role of Proteolytic Dysregulation.

International journal of molecular sciences

Avec: Vincent Mariaule , Aicha Kriaa , Souha Soussou , Soufien Rhimi , Houda Boudaya , Juan Hernandez , Emmanuelle Maguin , Adam Lesner , Moez Rhimi

Gut Serpinome: Emerging Evidence in IBD.

International journal of molecular sciences

Avec: Héla Mkaouar , Vincent Mariaule , Soufien Rhimi , Juan Hernandez , Aicha Kriaa , Amin Jablaoui , Nizar Akermi , Emmanuelle Maguin , Adam Lesner , Brice Korkmaz , Moez Rhimi

Chemical tools to monitor bladder cancer progression.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Avec: Natalia Gruba , Lech Stachurski , Adam Lesner

Réseau de co-auteurs

Natalia Gruba 17 collaborations

Magdalena Wysocka 13 collaborations

Brice Korkmaz 8 collaborations

Agnieszka Piwkowska 7 collaborations

Aicha Kriaa 6 collaborations

Emmanuelle Maguin 6 collaborations

Moez Rhimi 6 collaborations

Vincent Mariaule 5 collaborations

Amin Jablaoui 5 collaborations

Soufien Rhimi 4 collaborations

Patrycja Rachubik 4 collaborations

Souha Soussou 4 collaborations

Lech Stachurski 3 collaborations

Juan Hernandez 3 collaborations

Marlena Typiak 3 collaborations

Irena Audzeyenka 3 collaborations

Dorota Rogacka 3 collaborations

Francis Gauthier 3 collaborations

Ali Gargouri 3 collaborations

Ewa Bielecka 3 collaborations

Katherine Falkowski 3 collaborations

Grzegorz Dubin 3 collaborations

Tomasz Kantyka 3 collaborations

Jan Potempa 3 collaborations

Héla Mkaouar 3 collaborations

Cezary Czaplewski 2 collaborations

Artur Giełdoń 2 collaborations

Joanna Pianka 2 collaborations

Tomasz Kulesza 2 collaborations

Moin A Saleem 2 collaborations

Renata Grzywa 2 collaborations

Seda Seren 2 collaborations

Jonas Hahn 2 collaborations

Christine Schauer 2 collaborations

Georg Schett 2 collaborations

Artur Gieldon 2 collaborations

Dieter E Jenne 2 collaborations

Paulina Kosikowska-Adamus 2 collaborations

Anna Golda 2 collaborations

Adam Prahl 2 collaborations

Houda Boudaya 2 collaborations

Ali Amouri 2 collaborations

Anna Wojtysiak 2 collaborations

Magdalena Brzezińska-Bodal 2 collaborations

Kamila Sychowska 2 collaborations

Magdalena Kalińska 2 collaborations

Małgorzata Magoch 2 collaborations

Aleksandra Pęcak 2 collaborations

Magdalena Wiśniewska 2 collaborations

Laura Sąsiadek 2 collaborations

Karolina Płaza 2 collaborations

Anastasija Pejkovska 2 collaborations

Maren Rehders 2 collaborations

Klaudia Brix 2 collaborations

Anita Romanowska 2 collaborations

Emilia Sikorska 2 collaborations

Wiktoria Rejmak 2 collaborations

Honorata Sikora 2 collaborations

Nizar Akermi 2 collaborations

Mario Navarrete 1 collaboration

Carla Guarino 1 collaboration

Ying Lao 1 collaboration

Julie Ho 1 collaboration

Peter Nickerson 1 collaboration

John A Wilkins 1 collaboration

Hela Mkaouar 1 collaboration

Ali Aghdassi 1 collaboration

Iga Biskupek 1 collaboration

Adam Sieradzan 1 collaboration

Adam Liwo 1 collaboration

Stefan Angielski 1 collaboration

Michał Rychłowski 1 collaboration

Koffi N'Guessan 1 collaboration

Guillaume Gabant 1 collaboration

Maria A Juliano 1 collaboration

Marc Moniatte 1 collaboration

Alain van Dorsselaer 1 collaboration

Joseph G Bieth 1 collaboration

Christine Kellenberger 1 collaboration

Marcin Sienczyk 1 collaboration

Martine Cadene 1 collaboration

Christine Czegley 1 collaboration

Lasse Kling 1 collaboration

Lenka Petru 1 collaboration

Benjamin Schmid 1 collaboration

Daniela Weidner 1 collaboration

Christiane Reinwald 1 collaboration

Mona H C Biermann 1 collaboration

Stefan Blunder 1 collaboration

Jürgen Ernst 1 collaboration

Tobias Bäuerle 1 collaboration

Ralf Palmisano 1 collaboration

Silke Christiansen 1 collaboration

Martin Herrmann 1 collaboration

Aline Bozec 1 collaboration

Robert Gruber 1 collaboration

Markus H Hoffmann 1 collaboration

Maria Håkansson 1 collaboration

Derek T Logan 1 collaboration

Conni Lauritzen 1 collaboration

John Pedersen 1 collaboration

Jacek Ryl 1 collaboration

Magdalena Pilarczyk-Zurek 1 collaboration

Grzegorz Bereta 1 collaboration

Tadeusz Ossowski 1 collaboration

Joanna Koziel 1 collaboration

Paweł Niedziałkowski 1 collaboration

Urszula Zarzecka 1 collaboration

Anna Modrak-Wójcik 1 collaboration

Donata Figaj 1 collaboration

Malgorzata Apanowicz 1 collaboration

Agnieszka Bzowska 1 collaboration

Barbara Lipinska 1 collaboration

Anna Zawilak-Pawlik 1 collaboration

Steffen Backert 1 collaboration

Joanna Skorko-Glonek 1 collaboration

Eileen Kroll 1 collaboration

Marcin Sieńczyk 1 collaboration

Sylvain Marchand-Adam 1 collaboration

Celia Moss 1 collaboration

Katarzyna Węgrzyn 1 collaboration

Katarzyna Bury 1 collaboration

Aleksandra Gnatek 1 collaboration

Igor Konieczny 1 collaboration

Natalia Stach 1 collaboration

Abdulkarim Karim 1 collaboration

Przemyslaw Golik 1 collaboration

Radoslaw Kitel 1 collaboration

Katarzyna Pustelny 1 collaboration

Katarzyna Groborz 1 collaboration

Urszula Jankowska 1 collaboration

Sylwia Kedracka-Krok 1 collaboration

Benedykt Wladyka 1 collaboration

Marcin Drag 1 collaboration

Monika Musielak 1 collaboration

Maria Szrejder 1 collaboration

Aleksandra Milewska 1 collaboration

Magdalena Kulczycka 1 collaboration

Antonina Naskalska 1 collaboration

Pawel Mak 1 collaboration

Marek Ochman 1 collaboration

Maciej Urlik 1 collaboration

Elftherios Diamandis 1 collaboration

Ioannis Prassas 1 collaboration

Krzysztof Pyrc 1 collaboration

Anne-Sophie Lamort 1 collaboration

Yveline Hamon 1 collaboration

Laurent Coquet 1 collaboration

Fabien Lecaille 1 collaboration

Gilles Lalmanach 1 collaboration

Dieter Jenne 1 collaboration

Stefan Haskamp 1 collaboration

Heiko Bruns 1 collaboration

Madelaine Hahn 1 collaboration

Markus Hoffmann 1 collaboration

Anne Gregor 1 collaboration

Sabine Löhr 1 collaboration

Mark Ringer 1 collaboration

Cindy Flamann 1 collaboration

Benjamin Frey 1 collaboration

Christian T Thiel 1 collaboration

Arif B Ekici 1 collaboration

Stephan von Hörsten 1 collaboration

Gunter Aßmann 1 collaboration

Claudia Riepe 1 collaboration

Maximilien Euler 1 collaboration

Knut Schäkel 1 collaboration

Sandra Philipp 1 collaboration

Jörg C Prinz 1 collaboration

Rotraut Mößner 1 collaboration

Florina Kersting 1 collaboration

Michael Sticherling 1 collaboration

Abdelaziz Sefiani 1 collaboration

Jaber Lyahyai 1 collaboration

Wiebke Sondermann 1 collaboration

Vinzenz Oji 1 collaboration

Peter Schulz 1 collaboration

Dagmar Wilsmann-Theis 1 collaboration

Heinrich Sticht 1 collaboration

André Reis 1 collaboration

Steffen Uebe 1 collaboration

Silke Frey 1 collaboration

Ulrike Hüffmeier 1 collaboration

Dariusz Wyrzykowski 1 collaboration

Aleksandra Walewska 1 collaboration

Milena Deptuła 1 collaboration

Michał Obuchowski 1 collaboration

Michał Pikuła 1 collaboration

Justyna Ciesielska 1 collaboration

Michalina Michalska 1 collaboration

Ida B Thøgersen 1 collaboration

Oliwia Bocheńska 1 collaboration

Georgina Butler 1 collaboration

Christopher M Overall 1 collaboration

Andrzej Kozik 1 collaboration

Jan J Enghild 1 collaboration

Dominika Wołoszyn 1 collaboration

Thomas Kryza 1 collaboration

Nathalie Bock 1 collaboration

Scott Lovell 1 collaboration

Anja Rockstroh 1 collaboration

Melanie L Lehman 1 collaboration

Janaththani Panchadsaram 1 collaboration

Lakmali Munasinghage Silva 1 collaboration

Srilakshmi Srinivasan 1 collaboration

Cameron E Snell 1 collaboration

Elizabeth D Williams 1 collaboration

Ladan Fazli 1 collaboration

Martin Gleave 1 collaboration

Jyotsna Batra 1 collaboration

Colleen Nelson 1 collaboration

Edward W Tate 1 collaboration

Jonathan Harris 1 collaboration

John D Hooper 1 collaboration

Judith A Clements 1 collaboration

Kamila Kitowska 1 collaboration

Kamil Mieczkowski 1 collaboration

Rafał Sądej 1 collaboration