Digestive Inflammation: Role of Proteolytic Dysregulation.
digestive inflammation
gut microbiota
holobiont
protease
serpin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 Mar 2021
10 Mar 2021
Historique:
received:
08
02
2021
revised:
04
03
2021
accepted:
05
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
23
4
2021
Statut:
epublish
Résumé
Dysregulation of the proteolytic balance is often associated with diseases. Serine proteases and matrix metalloproteases are involved in a multitude of biological processes and notably in the inflammatory response. Within the framework of digestive inflammation, several studies have stressed the role of serine proteases and matrix metalloproteases (MMPs) as key actors in its pathogenesis and pointed to the unbalance between these proteases and their respective inhibitors. Substantial efforts have been made in developing new inhibitors, some of which have reached clinical trial phases, notwithstanding that unwanted side effects remain a major issue. However, studies on the proteolytic imbalance and inhibitors conception are directed toward host serine/MMPs proteases revealing a hitherto overlooked factor, the potential contribution of their bacterial counterpart. In this review, we highlight the role of proteolytic imbalance in human digestive inflammation focusing on serine proteases and MMPs and their respective inhibitors considering both host and bacterial origin.
Identifiants
pubmed: 33802197
pii: ijms22062817
doi: 10.3390/ijms22062817
pmc: PMC7999743
pii:
doi:
Substances chimiques
Serine Proteases
EC 3.4.-
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : Titan-ANR number ANR-18-CE18-0019-03
Organisme : Agence Nationale de la Recherche
ID : SerpinGuTarget ANR-CE16-0018-01
Organisme : Campus France
ID : CMCU-PHC Utique (No. 19G0819)-Campus France (41786NC)
Organisme : Horizon 2020
ID : Twinning European project MICAfrica 952583
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