Chemical tools to monitor bladder cancer progression.
Bladder cancer
cancer development
chromogenic substrates
Journal
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
ISSN: 1366-5804
Titre abrégé: Biomarkers
Pays: England
ID NLM: 9606000
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
pubmed:
10
5
2022
medline:
9
9
2022
entrez:
9
5
2022
Statut:
ppublish
Résumé
Bladder cancer (BCa) is the most common cancer of the urinary system. Due to its high incidence and recurrence, as well as limited progress in the effective treatment, BCa is a challenge for today's medicine. We used a set of chromogenic substrates to differentiate between the stages of bladder cancer progression (G1 ( The specific activity of enzymes in the urine of patients with confirmed bladder cancer was determined separately for three (G1, G2, G3) stages of the disease development. What is more, no activity was observed in urine of healthy people ( Research shows that specific enzymes are associated with the development of specific stages of cancer. We suspect that the differences in the proteolytic activity of urine samples are due to the presence of a different set of enzymes that are directly related to the particular stage of the disease. We obtained three substrates for monitoring individual stages of bladder cancer development.
Sections du résumé
BACKGROUND
UNASSIGNED
Bladder cancer (BCa) is the most common cancer of the urinary system. Due to its high incidence and recurrence, as well as limited progress in the effective treatment, BCa is a challenge for today's medicine.
MATERIALS AND METHODS
UNASSIGNED
We used a set of chromogenic substrates to differentiate between the stages of bladder cancer progression (G1 (
RESULTS
UNASSIGNED
The specific activity of enzymes in the urine of patients with confirmed bladder cancer was determined separately for three (G1, G2, G3) stages of the disease development. What is more, no activity was observed in urine of healthy people (
DISCUSSION
UNASSIGNED
Research shows that specific enzymes are associated with the development of specific stages of cancer. We suspect that the differences in the proteolytic activity of urine samples are due to the presence of a different set of enzymes that are directly related to the particular stage of the disease.
CONCLUSION
UNASSIGNED
We obtained three substrates for monitoring individual stages of bladder cancer development.
Identifiants
pubmed: 35532038
doi: 10.1080/1354750X.2022.2076153
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM