Bile Acids: Key Players in Inflammatory Bowel Diseases?


Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
05 03 2022
Historique:
received: 18 02 2022
revised: 28 02 2022
accepted: 03 03 2022
entrez: 10 3 2022
pubmed: 11 3 2022
medline: 12 4 2022
Statut: epublish

Résumé

Inflammatory bowel diseases (IBDs) have emerged as a public health problem worldwide with a limited number of efficient therapeutic options despite advances in medical therapy. Although changes in the gut microbiota composition are recognized as key drivers of dysregulated intestinal immunity, alterations in bile acids (BAs) have been shown to influence gut homeostasis and contribute to the pathogenesis of the disease. In this review, we explore the interactions involving BAs and gut microbiota in IBDs, and discuss how the gut microbiota-BA-host axis may influence digestive inflammation.

Identifiants

pubmed: 35269523
pii: cells11050901
doi: 10.3390/cells11050901
pmc: PMC8909766
pii:
doi:

Substances chimiques

Bile Acids and Salts 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Research Institute for Agriculture, Food and Environment
ID : MICA department
Organisme : Oniris
ID : Animal microbiota analysis project
Organisme : European Commission
ID : MICAfrica

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Auteurs

Aicha Kriaa (A)

Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute, AgroParisTech, Université Paris-Saclay, INRAE, 78350 Jouy-en-Josas, France.

Vincent Mariaule (V)

Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute, AgroParisTech, Université Paris-Saclay, INRAE, 78350 Jouy-en-Josas, France.

Amin Jablaoui (A)

Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute, AgroParisTech, Université Paris-Saclay, INRAE, 78350 Jouy-en-Josas, France.

Soufien Rhimi (S)

Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute, AgroParisTech, Université Paris-Saclay, INRAE, 78350 Jouy-en-Josas, France.

Hela Mkaouar (H)

Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute, AgroParisTech, Université Paris-Saclay, INRAE, 78350 Jouy-en-Josas, France.

Juan Hernandez (J)

Oniris, Department of Clinical Sciences, Nantes-Atlantic College of Veterinary Medicine and Food Sciences, University of Nantes, 101 Route de Gachet, 44300 Nantes, France.

Brice Korkmaz (B)

INSERM UMR-1100, "Research Center for Respiratory Diseases", University of Tours, 37032 Tours, France.

Adam Lesner (A)

Faculty of Chemistry, University of Gdansk, Uniwersytet Gdanski, Chemistry, Wita Stwosza 63, PL80-308 Gdansk, Poland.

Emmanuelle Maguin (E)

Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute, AgroParisTech, Université Paris-Saclay, INRAE, 78350 Jouy-en-Josas, France.

Ali Aghdassi (A)

Department of Medicine A, University Medicine Greifswald, 17489 Greifswald, Germany.

Moez Rhimi (M)

Microbiota Interaction with Human and Animal Team (MIHA), Micalis Institute, AgroParisTech, Université Paris-Saclay, INRAE, 78350 Jouy-en-Josas, France.

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