Detection of ADAM15 in urine from patients with bladder cancer.

ADAM Proteins Humans Male Membrane Proteins Peptides Urinary Bladder Neoplasms
ADAM15 Bladder cancer Proteolytic activity

Journal

Analytical biochemistry
ISSN: 1096-0309
Titre abrégé: Anal Biochem
Pays: United States
ID NLM: 0370535

Informations de publication

Date de publication:
01 10 2022
Historique:
received: 08 04 2022
revised: 04 07 2022
accepted: 04 07 2022
pubmed: 11 7 2022
medline: 24 8 2022
entrez: 10 7 2022
Statut: ppublish

Résumé

Cancer is one of the leading causes of death in the United States and Europe. Of the cancers, bladder cancer is the 10th most frequently diagnosed cancer and the 13th most frequently diagnosed cancer in men. There are many studies showing that proteolytic enzymes, e.g. A Disintegrin and Metalloproteinases (ADAMs), play a key role in the development and progression of neoplasms. In this paper, we present the use of chromogenic substrate of ADAM15 for the qualitative determination of specific activity of enzyme in urine of patients with confirmed bladder cancer. In the first step, we optimized the substrate molecule in non-primed positions using combinatorial chemistry. By means of the obtained ABZ-His-Ala-Arg-Gly-ANB-NH

Identifiants

DOI: 10.1016/j.ab.2022.114805 PMID: 35810783
pubmed: 35810783
pii: S0003-2697(22)00261-5
doi: 10.1016/j.ab.2022.114805
pii:
doi:

Substances chimiques

Membrane Proteins 0
Peptides 0
ADAM Proteins EC 3.4.24.-
ADAM15 protein, human EC 3.4.24.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114805

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Natalia Gruba (N)

Department of Environmental Technology, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63 Street, PL 80-308, Gdańsk, Poland. Electronic address: natalia.gruba@ug.edu.pl.

Monika Musielak (M)

Department of Environmental Technology, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63 Street, PL 80-308, Gdańsk, Poland.

Wiktoria Rejmak (W)

Department of Environmental Technology, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63 Street, PL 80-308, Gdańsk, Poland.

Adam Lesner (A)

Department of Environmental Technology, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63 Street, PL 80-308, Gdańsk, Poland.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Protéines ADAM › Detection of ADAM15 in urine from patients...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Detection of ADAM15 in urine from patients...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Detection of ADAM15 in urine from patients...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Detection of ADAM15 in urine from patients...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Tumeurs urologiques › Tumeurs de la vessie urinaire › Detection of ADAM15 in urine from patients...