Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases.
Adolescent
Adult
Animals
Chemokines
/ metabolism
Cytokines
/ metabolism
Extracellular Traps
/ metabolism
Humans
Inflammation
/ prevention & control
Inflammation Mediators
/ metabolism
Ionomycin
/ pharmacology
Male
Mice
Mice, Inbred BALB C
NADPH Oxidases
/ genetics
Neutrophils
/ drug effects
Periodontitis
/ metabolism
Protease Inhibitors
/ metabolism
Proteolysis
Tetradecanoylphorbol Acetate
/ pharmacology
Uric Acid
/ pharmacology
eosinophils
immune regulation
neutrophil serine proteases
periodontal inflammation
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
pubmed:
22
8
2018
medline:
19
9
2019
entrez:
22
8
2018
Statut:
ppublish
Résumé
Papillon-Lefèvre syndrome (PLS) is characterized by nonfunctional neutrophil serine proteases (NSPs) and fulminant periodontal inflammation of unknown cause. Here we investigated neutrophil extracellular trap (NET)-associated aggregation and cytokine/chemokine-release/degradation by normal and NSP-deficient human and mouse granulocytes. Stimulated with solid or soluble NET inducers, normal neutrophils formed aggregates and both released and degraded cytokines/chemokines. With increasing cell density, proteolytic degradation outweighed release. Maximum output of cytokines/chemokines occurred mostly at densities between 2 × 10
Identifiants
pubmed: 30130433
doi: 10.1096/fj.201800752R
pmc: PMC6355082
doi:
Substances chimiques
Chemokines
0
Cytokines
0
Inflammation Mediators
0
Protease Inhibitors
0
Uric Acid
268B43MJ25
Ionomycin
56092-81-0
NADPH Oxidases
EC 1.6.3.-
neutrophil cytosolic factor 1
EC 1.6.3.1
Tetradecanoylphorbol Acetate
NI40JAQ945
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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