A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome.
bladder cancer
fluorogenic substrates
libraries
peptidomimetics
proteasome
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Mar 2020
31 Mar 2020
Historique:
received:
02
03
2020
revised:
25
03
2020
accepted:
29
03
2020
entrez:
5
4
2020
pubmed:
5
4
2020
medline:
5
1
2021
Statut:
epublish
Résumé
This work describes the chemical synthesis, combinatorial selection, and enzymatic evaluation of peptidomimetic fluorescent substrates specific for the trypsin-like (β2) subunit of the 20S human proteasome. After deconvolution of a library comprising nearly 6000 compounds composed of peg substituted diaminopropionic acid DAPEG building blocks, the sequence ABZ-Dap(O2(Cbz))-Dap(GO1)-Dap(O2(Cbz))-Arg-ANB-NH
Identifiants
pubmed: 32244300
pii: ijms21072396
doi: 10.3390/ijms21072396
pmc: PMC7177456
pii:
doi:
Substances chimiques
Fluorescent Dyes
0
NCOR1 protein, human
0
Nuclear Receptor Co-Repressor 1
0
Peptidomimetics
0
ortho-Aminobenzoates
0
anthranilic acid
0YS975XI6W
Trypsin
EC 3.4.21.4
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowe Centrum Nauki
ID : UMO-2017/27/B/ST5/02061
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