SP-1, a Serine Protease from the Gut Microbiota, Influences Colitis and Drives Intestinal Dysbiosis in Mice.
Amino Acid Sequence
Animals
Colitis
/ chemically induced
Conserved Sequence
Dextran Sulfate
Dysbiosis
/ enzymology
Feces
/ enzymology
Gastrointestinal Microbiome
Inflammation
/ pathology
Intestinal Mucosa
/ pathology
Intestines
/ pathology
Kinetics
Lactobacillus
/ enzymology
Male
Mice, Inbred C57BL
Phylogeny
Serine Proteases
/ administration & dosage
Substrate Specificity
Subtilisin
/ chemistry
gut microbiota
holobiont
inflammatory bowel diseases
microbiome
serine proteases
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
05 10 2021
05 10 2021
Historique:
received:
28
07
2021
revised:
22
09
2021
accepted:
01
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Increased protease activity has been linked to the pathogenesis of IBD. While most studies have been focusing on host proteases in gut inflammation, it remains unclear how to address the potential contribution of their bacterial counterparts. In the present study, we report a functional characterization of a newly identified serine protease, SP-1, from the human gut microbiota. The serine protease repertoire of gut
Identifiants
pubmed: 34685638
pii: cells10102658
doi: 10.3390/cells10102658
pmc: PMC8534766
pii:
doi:
Substances chimiques
Dextran Sulfate
9042-14-2
Serine Proteases
EC 3.4.-
Subtilisin
EC 3.4.21.62
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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