Gut Serpinome: Emerging Evidence in IBD.
gut microbiota
gut serpinome
holobiont
inflammatory bowel diseases
proteases
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Jun 2021
04 Jun 2021
Historique:
received:
20
04
2021
revised:
01
06
2021
accepted:
03
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
27
7
2021
Statut:
epublish
Résumé
Inflammatory bowel diseases (IBD) are incurable disorders whose prevalence and global socioeconomic impact are increasing. While the role of host genetics and immunity is well documented, that of gut microbiota dysbiosis is increasingly being studied. However, the molecular basis of the dialogue between the gut microbiota and the host remains poorly understood. Increased activity of serine proteases is demonstrated in IBD patients and may contribute to the onset and the maintenance of the disease. The intestinal proteolytic balance is the result of an equilibrium between the proteases and their corresponding inhibitors. Interestingly, the serine protease inhibitors (serpins) encoded by the host are well reported; in contrast, those from the gut microbiota remain poorly studied. In this review, we provide a concise analysis of the roles of serine protease in IBD physiopathology and we focus on the serpins from the gut microbiota (gut serpinome) and their relevance as a promising therapeutic approach.
Identifiants
pubmed: 34200095
pii: ijms22116088
doi: 10.3390/ijms22116088
pmc: PMC8201313
pii:
doi:
Substances chimiques
Serpins
0
Serine Proteases
EC 3.4.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-18-CE18-0019-03
Organisme : Agence Nationale de la Recherche
ID : ANR-CE16-0018-01
Organisme : Campus France
ID : 41786NC
Organisme : Horizon 2020
ID : MICAfrica 952583
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