Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1.

Adult Anti-HIV Agents / pharmacology Antibodies, Neutralizing / blood Blood Transfusion, Autologous / methods CD4-Positive T-Lymphocytes / drug effects Cells, Cultured Combined Modality Therapy / methods Female HIV Antibodies / blood HIV Infections / blood HIV-1 / drug effects Humans Immunoglobulin G / blood Leukapheresis Male Middle Aged Primary Cell Culture Virus Latency / drug effects Virus Replication / drug effects env Gene Products, Human Immunodeficiency Virus / immunology
HIV QVOA latency neutralizing antibody reservoir

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
15 12 2020
Historique:
pubmed: 27 11 2020
medline: 2 2 2021
entrez: 26 11 2020
Statut: ppublish

Résumé

In untreated HIV-1 infection, rapid viral evolution allows escape from immune responses. Viral replication can be blocked by antiretroviral therapy. However, HIV-1 persists in a latent reservoir in resting CD4

Identifiants

DOI: 10.1073/pnas.2020617117 PMID: 33239444 PMC: PMC7749285
pubmed: 33239444
pii: 2020617117
doi: 10.1073/pnas.2020617117
pmc: PMC7749285
doi:

Substances chimiques

Anti-HIV Agents 0
Antibodies, Neutralizing 0
HIV Antibodies 0
Immunoglobulin G 0
env Gene Products, Human Immunodeficiency Virus 0

Types de publication

Journal Article Observational Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

32066-32077

Subventions

Organisme : NIAID NIH HHS
ID : UM1 AI126620
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI094189
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI045008
Pays : United States
Organisme : NIH HHS
ID : T32 OD011089
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI126603
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI069534
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no competing interest.

Références

Annu Rev Virol. 2017 Sep 29;4(1):261-285
pubmed: 28715973
J Virol. 2006 Jul;80(13):6441-57
pubmed: 16775332
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2575-E2584
pubmed: 29483265
Science. 1997 Nov 14;278(5341):1295-300
pubmed: 9360927
N Engl J Med. 2016 Nov 24;375(21):2037-2050
pubmed: 27959728
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8869-73
pubmed: 9671771
Science. 1994 Nov 11;266(5187):1024-7
pubmed: 7973652
Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4819-24
pubmed: 12684537
J Infect Dis. 2017 Jul 15;216(2):254-262
pubmed: 28838149
PLoS Pathog. 2016 Aug 05;12(8):e1005689
pubmed: 27494508
J Exp Med. 2018 Sep 3;215(9):2311-2324
pubmed: 30072495
Immunity. 2019 Mar 19;50(3):567-575.e5
pubmed: 30850342
Immunity. 2012 Sep 21;37(3):412-25
pubmed: 22999947
Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11341-E11348
pubmed: 30420517
Science. 2003 Jun 27;300(5628):2065-71
pubmed: 12829775
Sci Transl Med. 2019 Oct 9;11(513):
pubmed: 31597754
Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13800-5
pubmed: 20643940
PLoS Pathog. 2012 Feb;8(2):e1002506
pubmed: 22319447
Science. 1997 Nov 14;278(5341):1291-5
pubmed: 9360926
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13193-7
pubmed: 9371822
Virology. 1991 Jun;182(2):635-43
pubmed: 1708933
PLoS Pathog. 2020 Feb 5;16(2):e1008286
pubmed: 32023326
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4144-9
pubmed: 12644702
Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1126-34
pubmed: 25713386
J Virol. 1994 Sep;68(9):6103-10
pubmed: 8057491
J Clin Invest. 2017 Jun 30;127(7):2689-2696
pubmed: 28628034
Nat Med. 2016 Sep;22(9):1043-9
pubmed: 27500724
J Virol. 2005 Aug;79(15):9625-34
pubmed: 16014925
J Virol. 2019 Apr 3;93(8):
pubmed: 30700598
J Exp Med. 2017 Apr 3;214(4):959-972
pubmed: 28341641
J Virol. 2009 Jul;83(14):7337-48
pubmed: 19439467
Nature. 2016 Jul 28;535(7613):556-60
pubmed: 27338952
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16538-43
pubmed: 24043801
Methods Mol Biol. 2005;304:3-15
pubmed: 16061962
Methods Mol Biol. 2016;1354:239-53
pubmed: 26714716
Nature. 2009 Apr 2;458(7238):636-40
pubmed: 19287373
J Immunol Methods. 2014 Jul;409:131-46
pubmed: 24291345
AIDS. 1990 Feb;4(2):107-12
pubmed: 2328092
Nature. 2013 Nov 14;503(7475):224-8
pubmed: 24172905
Immunity. 2019 Feb 19;50(2):520-532.e3
pubmed: 30709739
Methods Mol Biol. 2009;485:395-405
pubmed: 19020839
Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7908-E7916
pubmed: 27872306
Nature. 2014 Aug 7;512(7512):74-7
pubmed: 25042999
Nat Med. 2008 Jul;14(7):762-6
pubmed: 18552857
Nature. 2012 Jul 25;487(7408):439-40
pubmed: 22836995
Sci Transl Med. 2014 Jul 2;6(243):243ra88
pubmed: 24990883
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1883-8
pubmed: 26858442
Nat Med. 2009 Aug;15(8):893-900
pubmed: 19543283
Science. 1999 Feb 5;283(5403):857-60
pubmed: 9933172
Nat Med. 2003 Jun;9(6):727-8
pubmed: 12754504
Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E590-E599
pubmed: 28069935
J Virol. 2018 Nov 12;92(23):
pubmed: 30209173
Immunity. 2018 May 15;48(5):872-895
pubmed: 29768175
Science. 2016 May 20;352(6288):1001-4
pubmed: 27199430
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15109-14
pubmed: 10611346
Sci Transl Med. 2015 Dec 23;7(319):319ra206
pubmed: 26702094
Cell. 2013 Oct 24;155(3):540-51
pubmed: 24243014
Nature. 2013 Nov 14;503(7475):277-80
pubmed: 24172896
PLoS Pathog. 2017 Mar 22;13(3):e1006283
pubmed: 28328934
Science. 2014 Jul 11;345(6193):179-83
pubmed: 24968937
Nature. 2014 Oct 30;514(7524):642-5
pubmed: 25119033
Cell. 2014 Aug 28;158(5):989-999
pubmed: 25131989
Nature. 2012 Jul 25;487(7408):482-5
pubmed: 22837004
Nature. 2003 Mar 20;422(6929):307-12
pubmed: 12646921
Science. 2001 Aug 10;293(5532):1155-9
pubmed: 11498595
Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13151-6
pubmed: 25157148
J Exp Med. 2020 Jul 6;217(7):
pubmed: 32311008
Nature. 2019 Feb;566(7742):120-125
pubmed: 30700913
Science. 2014 Aug 1;345(6196):570-3
pubmed: 25011556
Nature. 1987 Jul 23-29;328(6128):345-8
pubmed: 3496541
J Clin Invest. 2018 Jul 2;128(7):3102-3115
pubmed: 29911997
Nat Med. 2018 Nov;24(11):1701-1707
pubmed: 30258217
Nature. 2018 Nov;563(7731):360-364
pubmed: 30283138
Nat Immunol. 2015 Jun;16(6):571-6
pubmed: 25988889
J Infect Dis. 2015 Nov 1;212(9):1361-5
pubmed: 25877550
Nature. 2016 May 5;533(7601):105-109
pubmed: 27120156
Nat Med. 2000 Feb;6(2):207-10
pubmed: 10655111
J Virol. 1993 Jul;67(7):4104-13
pubmed: 8510218
Nat Med. 2017 Feb;23(2):185-191
pubmed: 28092665
J Virol. 1994 Jul;68(7):4650-5
pubmed: 8207839
Nature. 2012 Dec 6;492(7427):118-22
pubmed: 23103874
Nat Commun. 2015 Sep 29;6:8443
pubmed: 26416571

Auteurs

Lynn N Bertagnolli (LN)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Joseph Varriale (J)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
ORCID: 0000-0002-9663-3325

Sarah Sweet (S)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Jacqueline Brockhurst (J)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Francesco R Simonetti (FR)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
ORCID: 0000-0002-4165-660X

Jennifer White (J)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Subul Beg (S)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Kenneth Lynn (K)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Karam Mounzer (K)

Jonathan Lax Center, Philadelphia Field Initiative Group HIV Trials, Philadelphia, PA 19107.

Ian Frank (I)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Pablo Tebas (P)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Katharine J Bar (KJ)

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Luis J Montaner (LJ)

HIV Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, PA 19104.
ORCID: 0000-0001-5799-6759

Robert F Siliciano (RF)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; rsiliciano@jhmi.edu.
Howard Hughes Medical Institute, Baltimore, MD 21205.
ORCID: 0000-0002-1764-1993

Janet D Siliciano (JD)

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Agents antiVIH › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Thérapeutique › Biothérapie › Transfusion sanguine › Transfusion sanguine autologue › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Cellules › Cellules cultivées › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Thérapeutique › Association thérapeutique › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Anticorps antideltarétrovirus › Anticorps anti-VIH › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Séparation cellulaire › Cytaphérèse › Leucaphérèse › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Latence virale › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Autologous IgG antibodies block outgrowth of a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Produits du gène env › Produits du gène env du virus de l'immunodéficience humaine › Autologous IgG antibodies block outgrowth of a...