Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage.
Pumilio
RNA stability
RNA-seq
translesion synthesis
Journal
Molecular & cellular oncology
ISSN: 2372-3556
Titre abrégé: Mol Cell Oncol
Pays: United States
ID NLM: 101642411
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
26
11
2020
pubmed:
27
11
2020
medline:
27
11
2020
Statut:
epublish
Résumé
Biological roles of Pumilio1 (PUM1) in ubiquitous cells remain unclear. Here we identify 48 degrading target mRNAs by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs. Further analysis revealed that cells respond to DNA damage by inhibiting PUM1-mediated mRNA decay to activate translesion synthesis (46/50).
Identifiants
pubmed: 33241107
doi: 10.1080/23723556.2020.1812868
pii: 1812868
pmc: PMC7671024
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1812868Informations de copyright
© 2020 Taylor & Francis Group, LLC.
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