Cuprizone-induced demyelination triggers a CD8-pronounced T cell recruitment.
cuprizone
multiple sclerosis
neuroinflammation
oligodendrocyte injury
peripheral immune cell recruitment
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
30
07
2020
revised:
06
11
2020
accepted:
11
11
2020
pubmed:
28
11
2020
medline:
8
2
2022
entrez:
27
11
2020
Statut:
ppublish
Résumé
The loss of myelinating oligodendrocytes is a key characteristic of many neurological diseases, including Multiple Sclerosis (MS). In progressive MS, where effective treatment options are limited, peripheral immune cells can be found at the site of demyelination and are suggested to play a functional role during disease progression. In this study, we hypothesize that metabolic oligodendrocyte injury, caused by feeding the copper chelator cuprizone, is a potent trigger for peripheral immune cell recruitment into the central nervous system (CNS). We used immunohistochemistry and flow cytometry to evaluate the composition, density, and activation status of infiltrating T lymphocytes in cuprizone-intoxicated mice and post-mortem progressive MS tissues. Our results demonstrate a predominance of CD8
Substances chimiques
Cuprizone
5N16U7E0AO
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
925-942Informations de copyright
© 2020 The Authors. GLIA published by Wiley Periodicals LLC.
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