Significant correlation between gross tumor volume (GTV) D98% and local control in multifraction stereotactic radiotherapy (MF-SRT) for unresected brain metastases.
Brain metastases
GTV D98%
Local control
Stereotactic radiotherapy
VMAT
Journal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
15
09
2020
revised:
10
11
2020
accepted:
16
11
2020
pubmed:
28
11
2020
medline:
24
4
2021
entrez:
27
11
2020
Statut:
ppublish
Résumé
Stereotactic radiotherapy (SRT) should be applied with a biologically effective dose with an α/β of 12 (BED Included in this study were the first 81 brain metastases (BM) consecutively treated with Linac-based volumetric modulated arc therapy (VMAT) multifraction SRT from 2017 to 2019. The prescribed dose was 33 Gy for the GTV and 23.1 Gy (70% isodose line) for the PTV in 3 fractions (3f). Mean BM largest diameter and GTV were 25.1 mm and 7.2 cc respectively. Mean follow-up was 10.2 months. LC was 79.7% and 69.7% at 1 and 2 years respectively. Significant predictive factors of LC were GTV D The GTV D
Sections du résumé
BACKGROUND
Stereotactic radiotherapy (SRT) should be applied with a biologically effective dose with an α/β of 12 (BED
METHODS
Included in this study were the first 81 brain metastases (BM) consecutively treated with Linac-based volumetric modulated arc therapy (VMAT) multifraction SRT from 2017 to 2019. The prescribed dose was 33 Gy for the GTV and 23.1 Gy (70% isodose line) for the PTV in 3 fractions (3f). Mean BM largest diameter and GTV were 25.1 mm and 7.2 cc respectively. Mean follow-up was 10.2 months.
RESULTS
LC was 79.7% and 69.7% at 1 and 2 years respectively. Significant predictive factors of LC were GTV D
CONCLUSION
The GTV D
Identifiants
pubmed: 33245944
pii: S0167-8140(20)31191-9
doi: 10.1016/j.radonc.2020.11.021
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
260-268Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.