Pathology of TB/COVID-19 Co-Infection: The phantom menace.


Journal

Tuberculosis (Edinburgh, Scotland)
ISSN: 1873-281X
Titre abrégé: Tuberculosis (Edinb)
Pays: Scotland
ID NLM: 100971555

Informations de publication

Date de publication:
01 2021
Historique:
received: 14 07 2020
revised: 10 09 2020
accepted: 10 11 2020
pubmed: 28 11 2020
medline: 25 2 2021
entrez: 27 11 2020
Statut: ppublish

Résumé

Tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are currently the two main causes of death among infectious diseases. There is an increasing number of studies trying to elucidate the interactions between Mycobacterium tuberculosis and SARS-CoV-2. Some of the first case reports point to a worsening of respiratory symptoms in co-infected TB/COVID-19 individuals. However, data from the cohort studies has shown some conflicting results. This study proposes to conduct a systematic review on the current literature on TB/COVID-19 co-infection cohorts, evaluating clinical and epidemiological data, focusing on its implications to the immune system. From an immunological perspective, the TB/COVID-19 co-infection has the potential to converge in a "perfect storm". The disorders induced by each pathogen to the immunomodulation tend to induce an unbalanced inflammatory response, which can promote the progression and worsening of both diseases. Understanding the nature of the interactions between M. tuberculosis and SARS-CoV-2 will be crucial for the development of therapeutic strategies against co-infection.

Identifiants

pubmed: 33246269
pii: S1472-9792(20)30187-6
doi: 10.1016/j.tube.2020.102020
pmc: PMC7669479
pii:
doi:

Substances chimiques

Inflammation Mediators 0

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102020

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Gabriel Tassi Mousquer (GT)

Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil. Electronic address: gabriel_mousquer@hotmail.com.

Alessandra Peres (A)

Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil; Basic Health Sciences Department, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil. Electronic address: peres@ufcspa.edu.br.

Marilu Fiegenbaum (M)

Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil; Basic Health Sciences Department, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Brazil. Electronic address: marilu.fiegenbaum@gmail.com.

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