Supercritical fluid chromatography - Mass spectrometry in metabolomics: Past, present, and future perspectives.
Bioanalysis
Lipidomics
Mass spectrometry
Metabolomics
Supercritical fluid chromatography
Unified chromatography
Journal
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
ISSN: 1873-376X
Titre abrégé: J Chromatogr B Analyt Technol Biomed Life Sci
Pays: Netherlands
ID NLM: 101139554
Informations de publication
Date de publication:
15 Dec 2020
15 Dec 2020
Historique:
received:
12
09
2020
revised:
13
10
2020
accepted:
15
10
2020
pubmed:
28
11
2020
medline:
30
4
2021
entrez:
27
11
2020
Statut:
ppublish
Résumé
Metabolomics, which consists of the comprehensive analysis of metabolites within a biological system, has been playing a growing role in the implementation of personalized medicine in modern healthcare. A wide range of analytical approaches are used in metabolomics, notably mass spectrometry (MS) combined to liquid chromatography (LC), gas chromatography (GC), or capillary electrophoresis (CE). However, none of these methods enable a comprehensive analysis of the metabolome, due to its extreme complexity and the large differences in physico-chemical properties between metabolite classes. In this context, supercritical fluid chromatography (SFC) represents a promising alternative approach to improve the metabolome coverage, while further increasing the analysis throughput. SFC, which uses supercritical CO
Identifiants
pubmed: 33246285
pii: S1570-0232(20)31320-9
doi: 10.1016/j.jchromb.2020.122444
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
122444Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.