The significance of tyrosine kinase receptor B and brain-derived neurotrophic factor expression in salivary duct carcinoma.
Adenoma, Pleomorphic
/ complications
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ analysis
Brain-Derived Neurotrophic Factor
/ metabolism
Carcinoma, Ductal
/ diagnosis
Female
Humans
Immunohistochemistry
/ methods
Male
Membrane Glycoproteins
/ metabolism
Middle Aged
Neoplasm Staging
/ methods
Nerve Growth Factors
/ metabolism
RNA, Messenger
/ genetics
Receptor Protein-Tyrosine Kinases
/ metabolism
Receptor, trkB
/ metabolism
Salivary Ducts
/ metabolism
Salivary Gland Neoplasms
/ pathology
Brain-derived neurotrophic factor
De novo
Ex-pleomorphic adenoma
Neurotrophin-4
Salivary duct carcinoma
Tyrosine kinase receptor B
Journal
Annals of diagnostic pathology
ISSN: 1532-8198
Titre abrégé: Ann Diagn Pathol
Pays: United States
ID NLM: 9800503
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
10
06
2020
revised:
04
11
2020
accepted:
19
11
2020
pubmed:
29
11
2020
medline:
21
10
2021
entrez:
28
11
2020
Statut:
ppublish
Résumé
Salivary duct carcinoma (SDC) is a high-grade salivary gland neoplasm. It may occur de novo or secondarily from pleomorphic adenoma (ex-PA), with secondary development accounting for more than 50% of the cases. In recent years, the expression of tyrosine kinase receptor B (TrkB), which is in the same family as HER2, has been confirmed in various types of carcinomas. However, there are a few studies on SDC. In order to examine the expression and role of TrkB in SDC, we investigated it. Immunohistochemistry was used to detect the expression of TrkB and its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) in 20 patients with SDC. The mRNA levels of TrkB, BDNF, and NT-4 were analyzed using quantitative polymerase chain reaction. TrkB was negative in 10 cases and positive in 10 cases, BDNF was negative in 11 cases and positive in 9 cases, and NT-4 was positive in all cases. There was a high number of TrkB-positive cases in the pT4 group and The H-score of TrkB was also significantly higher in the stage III and IV groups. There was a high number of BDNF-positive cases in the ex-PA group and Histo-score of BDNF had a trend of high expression in ex-PA. There were no significant differences or correlations in mRNA expression. Our results suggest that TrkB may be involved in SDC tumor growth.
Identifiants
pubmed: 33248386
pii: S1092-9134(20)30219-7
doi: 10.1016/j.anndiagpath.2020.151673
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Brain-Derived Neurotrophic Factor
0
Membrane Glycoproteins
0
Nerve Growth Factors
0
RNA, Messenger
0
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
Receptor, trkB
EC 2.7.10.1
tropomyosin-related kinase-B, human
EC 2.7.10.1
neurotrophin 4
P658DCA9XD
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
151673Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.