Consistency checks to improve measurement with the Personal and Social Performance Scale (PSP).

International Society for CNS Clinical Trials and Methodology convened an expert Working Group that assembled consistency/inconsistency flags for the Personal and Social Performance Scale (PSP). One hundred and forty seven flags were identified, 16 flag errors in deriving the PSP decile (i.e., total) score from the four individual domain scores, 74 flag inconsistencies between domain scores relative to Positive and Negative Symptom Scale (PANSS) item ratings and 57 flag inconsistencies between PSP decile score and PANSS items ratings. The flags were applied to assessments from randomized clinical trial data of antipsychotics in schizophrenia from almost 18,000 ratings. Twenty-two flags were raised in at least 5 of 1000 ratings. Nearly 20% of the PSP ratings had at least one inconsistency flag raised. Application of flags to clinical ratings may improve the reliability of ratings and validity of trials.

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Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest Jonathan Rabinowitz has received research grant(s) support and/or travel support and/or speaker fees and/or consultant fees from Janssen Research and Development (J&J), Eli Lilly and Company, Pfizer, Lundbeck, Roche, Abraham Pharmaceuticals, Pierre Fabre, Intra-cellular Therapies, Minerva Foundation, Takeda and Amgen. Mark Opler is an employee and shareholder of WCG MedAvante-ProPhase Inc. and has received grant funding from Stanley Foundation, QNRF, and NIH. Alon A. Rabinowitz has no conflicts of interest to disclose. Selam Negash is an employee of WCG – MedAvante-ProPhase. Ariana Anderson has received grants or contracts from Janssen Research and Development and BlackThorn Therapeutics. Dong-Jing Fu is an employee of Janssen Research & Development, LLC and a stockholder of Johnson & Johnson. David Williamson is an employee of Janssen Scientific Affairs, LLC and a stockholder of Johnson & Johnson. Alan Kott is a Full time Employee of Signant Health, LLC. Lori L. Davis reports consulting income from Lundbeck, Otsuka, Janssen and research support from Alkermes, Aptinyx, Tonix. Nina R. Schooler has received honoraria and travel support for attendance at advisory board meetings or consultation from Alkermes, GW Pharmaceuticals, Intracellular Therapies, Lundbeck and Otsuka. She has received grant support from Otskua.