Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases.

Adolescent Adult Age Factors Aged Aged, 80 and over Alcohol Drinking / adverse effects Carcinoma, Mucoepidermoid / secondary Chemoradiotherapy, Adjuvant Databases, Factual Diabetes Complications / complications Disease-Free Survival Follow-Up Studies France Humans Lymphatic Metastasis Middle Aged Neck Dissection Neoplasm Grading Neoplasm Recurrence, Local / pathology Neoplasm Staging Prospective Studies Radiotherapy, Adjuvant Salivary Gland Neoplasms / pathology Survival Rate Young Adult

Cancer Mucoepidermoid carcinoma Parotid gland Salivary glands

Journal

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

ISSN: 1532-2157

Titre abrégé: Eur J Surg Oncol

Pays: England

ID NLM: 8504356

Informations de publication

Date de publication:
06 2021

Historique:

received: 12 08 2020

revised: 31 10 2020

accepted: 13 11 2020

pubmed: 30 11 2020

medline: 12 10 2021

entrez: 29 11 2020

Statut: ppublish

Résumé

To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival. Patients with MEC were prospectively included in the Réseau d'Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015. A total of 292 patients were included. Tumors were classified as low grade in 175 cases (60%), intermediate in 39 (13%) and high grade in 78 (27%). Median follow-up was 26 months. The 5-year OS and DFS rates were respectively 83% and 69%. In multivariate analysis, age (p = 0.004), diabetes (p = 0.02) and advanced stage (p = 0.03) were found to have a significant negative impact on OS. Diabetes (p = 0.001), alcohol consumption (p = 0.003) and advanced stage (p = 0.001) were found to have a significant negative impact on DFS. Compare to low grade, high grade tended to have a negative impact on OS (p = 0.05) and had a significant effect on DFS (0.002) while intermediate grade had no significant influence on survival. The surgical treatment had a positive impact on both OS (p = 0.00005) and DFS (p = 0.0005). Postoperative radiotherapy had no impact in multivariate analysis. Advanced clinical stage, high grade tumor, high age, the impossibility of carrying out a complete surgical resection, and diabetes are the main prognostic factors in this prospective series of patients with MEC. Such findings open new research perspectives on the influence of these components on initial patient care.

Sections du résumé

BACKGROUND

To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival.

PATIENTS AND METHODS

Patients with MEC were prospectively included in the Réseau d'Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015.

RESULTS

A total of 292 patients were included. Tumors were classified as low grade in 175 cases (60%), intermediate in 39 (13%) and high grade in 78 (27%). Median follow-up was 26 months. The 5-year OS and DFS rates were respectively 83% and 69%. In multivariate analysis, age (p = 0.004), diabetes (p = 0.02) and advanced stage (p = 0.03) were found to have a significant negative impact on OS. Diabetes (p = 0.001), alcohol consumption (p = 0.003) and advanced stage (p = 0.001) were found to have a significant negative impact on DFS. Compare to low grade, high grade tended to have a negative impact on OS (p = 0.05) and had a significant effect on DFS (0.002) while intermediate grade had no significant influence on survival. The surgical treatment had a positive impact on both OS (p = 0.00005) and DFS (p = 0.0005). Postoperative radiotherapy had no impact in multivariate analysis.

CONCLUSION

Advanced clinical stage, high grade tumor, high age, the impossibility of carrying out a complete surgical resection, and diabetes are the main prognostic factors in this prospective series of patients with MEC. Such findings open new research perspectives on the influence of these components on initial patient care.

Identifiants

DOI: 10.1016/j.ejso.2020.11.123 PMID: 33248902

pubmed: 33248902

pii: S0748-7983(20)31019-2

doi: 10.1016/j.ejso.2020.11.123

pii:

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

1376-1383

Investigateurs

S Albert (S)

G Andry (G)

E Babin (E)

C Bach (C)

J-M Badet (JM)

C Badoual (C)

A C Baglin (AC)

A Banal (A)

B Barry (B)

E Baudin (E)

B Baujat (B)

R J Bensadoun (RJ)

C Bertolus (C)

J-P Bessède (JP)

D Blanchard (D)

C Borel (C)

A Bozorg-Grayeli (A)

R Breheret (R)

P Breton (P)

L Brugel (L)

G Calais (G)

O Casiraghi (O)

E Cassagnau (E)

L Castillo (L)

P Ceruse (P)

F Chabolle (F)

D Chevalier (D)

J C Chobaut (JC)

O Choussy (O)

A Cosmidis (A)

A Coste (A)

V Costes (V)

L Crampette (L)

V Darrouzet (V)

P Demez (P)

P Dessi (P)

B Devauchelle (B)

G Dolivet (G)

F Dubrulle (F)

S Duflo (S)

X Dufour (X)

S Faivre (S)

N Fakhry (N)

C Ferron (C)

F Floret (F)

L de Gabory (L)

R Garrel (R)

L Geoffrois (L)

L Gilain (L)

A Giovanni (A)

A Girod (A)

B Guerrier (B)

S Hans (S)

P Herman (P)

P Hofman (P)

M Housset (M)

R Jankowski (R)

F Jegoux (F)

M Juliéron (M)

M-C Kaminsky (MC)

F Kolb (F)

J Lacau St Guily (JL)

L Laccoureye (L)

B Lallemant (B)

P Lang (P)

E Lartigau (E)

J-P Lavieille (JP)

M Lefevre (M)

X Leroy (X)

O Malard (O)

F Massip (F)

O Mauvais (O)

J-C Merol (JC)

J Michel (J)

T Mom (T)

S Morinière (S)

E de Monès (E)

G Moulin (G)

G Noel (G)

G Poissonnet (G)

J-M Prades (JM)

T Radulesco (T)

D de Raucourt (D)

E Reyt (E)

C Righini (C)

Y Marie Robin (YM)

F Rolland (F)

B Ruhin (B)

N Sarroul (N)

P Schultz (P)

E Serrano (E)

O Sterkers (O)

V Strunski (V)

A Sudaka (A)

M Tassart (M)

S Testelin (S)

J Thariat (J)

A Timochenko (A)

B Toussaint (B)

E Uro Coste (EU)

G Valette (G)

T Van den Abbeele (T)

A Varoquaux (A)

F Veillon (F)

S Vergez (S)

M Wassef (M)

Commentaires et corrections

Type : CommentIn

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of competing interest The authors have no conflicts of interest to disclose.