Histamine-4 receptor antagonist ameliorates Parkinson-like pathology in the striatum.

Animals Corpus Striatum / drug effects Disease Models, Animal Microglia / metabolism Nerve Degeneration / pathology Parkinson Disease / drug therapy Rats Receptors, Histamine H4 / antagonists & inhibitors Substantia Nigra / metabolism alpha-Synuclein / metabolism
Histamine-4 receptor antagonist Microglia Neurotransmitters Parkinson’s disease Postmortem human brain Striatum α-synuclein

Journal

Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478

Informations de publication

Date de publication:
02 2021
Historique:
received: 28 07 2020
revised: 22 11 2020
accepted: 23 11 2020
pubmed: 30 11 2020
medline: 28 5 2021
entrez: 29 11 2020
Statut: ppublish

Résumé

Growing evidence indicates that microglia activation and a neuroinflammatory trigger contribute to dopaminergic cell loss in Parkinson's disease (PD). Furthermore, increased density of histaminergic fibers and enhanced histamine levels have been observed in the substantia nigra of PD-postmortem brains. Histamine-induced microglial activation is mediated by the histamine-4 receptor (H

Identifiants

DOI: 10.1016/j.bbi.2020.11.036 PMID: 33249171
pubmed: 33249171
pii: S0889-1591(20)32412-0
doi: 10.1016/j.bbi.2020.11.036
pii:
doi:

Substances chimiques

Receptors, Histamine H4 0
alpha-Synuclein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

127-138

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Qiuyuan Fang (Q)

College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.

Helena Xicoy (H)

Dept. Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, The Netherlands; Dept. Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Neuroscience, Faculty of Science, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, The Netherlands.

Junqing Shen (J)

College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China.

Sabina Luchetti (S)

Dept. Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47 1105BA, Amsterdam, The Netherlands; Dept. Neuroimmunology, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47 1105BA, Amsterdam, The Netherlands.

Di Dai (D)

Technology Centre of Dalian Customs District P.R.China, Dalian, Liaoning 116001, China.

Pei Zhou (P)

College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China; Department of Infectious Diseases, Southwest Hospital, Army Medical University, Chongqing 400038, China.

Xin-Rui Qi (XR)

Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai 200072, China.

Gerard J M Martens (GJM)

Dept. Molecular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Neuroscience, Faculty of Science, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, The Netherlands.

Inge Huitinga (I)

Dept. Neuroimmunology, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47 1105BA, Amsterdam, The Netherlands; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.

Dick F Swaab (DF)

Dept. Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47 1105BA, Amsterdam, The Netherlands.

Chunqing Liu (C)

College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning 116044, China. Electronic address: liuchunqing@dmu.edu.cn.

Ling Shan (L)

Dept. Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47 1105BA, Amsterdam, The Netherlands. Electronic address: L.shan@nin.knaw.nl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Histamine-4 receptor antagonist ameliorates...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Histamine-4 receptor antagonist ameliorates...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Histamine-4 receptor antagonist ameliorates...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Histamine-4 receptor antagonist ameliorates...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dégénérescence nerveuse › Histamine-4 receptor antagonist ameliorates...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Histamine-4 receptor antagonist ameliorates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Histamine-4 receptor antagonist ameliorates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs histaminergiques › Récepteur histaminergique H4 › Histamine-4 receptor antagonist ameliorates...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Substantia nigra › Histamine-4 receptor antagonist ameliorates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Histamine-4 receptor antagonist ameliorates...