Fish oil supplementation enhances colon recovery after experimental colitis.
Colitis
Fish oil supplemenation
Inflammatory bowel disease
Omega-3 polyunsaturated fatty acids
Trinitrobenzenesulfonic acid
Journal
Prostaglandins, leukotrienes, and essential fatty acids
ISSN: 1532-2823
Titre abrégé: Prostaglandins Leukot Essent Fatty Acids
Pays: Scotland
ID NLM: 8802730
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
19
07
2020
revised:
10
11
2020
accepted:
11
11
2020
pubmed:
30
11
2020
medline:
3
6
2021
entrez:
29
11
2020
Statut:
ppublish
Résumé
Fish oil (FO) has an anti-inflammatory and pro-resolution activity and it has been used to restore physiological disturbances on inflammatory conditions. Here, we investigate whether FO supplementation could, acutely, prevent or restore inflammatory damages on experimental colitis. Wistar rats orally received 2 g.kg Experimental colitis did cause colon disruption and FO, acutely, did not prevent the loss of intestinal and fecal mucus, neither the increase of inflammatory activity and intestinal permeability. On the 7th day of colitis, FO soften the perturbations of experimental colitis, increasing histological and fecal mucus and, also decreased inflammatory activity, but this was not accompanied by intestinal permeability. FO did not protect, acutely, intestinal damages from experimental colitis, but at long run promotes higher intestinal recovery.
Identifiants
pubmed: 33249348
pii: S0952-3278(20)30170-8
doi: 10.1016/j.plefa.2020.102212
pii:
doi:
Substances chimiques
Fish Oils
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102212Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.