Selective internal radiation therapy of hepatic tumors: Morphologic and functional imaging for voxel-based computer-aided dosimetry.
Aged
Carcinoma, Hepatocellular
/ diagnostic imaging
Female
Humans
Liver Neoplasms
/ diagnostic imaging
Male
Middle Aged
Positron Emission Tomography Computed Tomography
/ methods
Radiotherapy Planning, Computer-Assisted
/ methods
Radiotherapy, Computer-Assisted
/ methods
Retrospective Studies
Single Photon Emission Computed Tomography Computed Tomography
/ methods
Yttrium Radioisotopes
/ metabolism
Hepatic tumors
SIRT
Survival
Voxel-based dosimetry
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
03
09
2020
revised:
01
10
2020
accepted:
05
10
2020
pubmed:
2
12
2020
medline:
18
2
2021
entrez:
1
12
2020
Statut:
ppublish
Résumé
Selective Internal Radiation Therapy (SIRT) is used for the treatment of hepatic tumors. The aim of this retrospective study was to compare two dosimetric approaches based on A total of 19 patients underwent 21 SIRT after baseline angiography and 99mTc-MAA SPECT/CT, followed by 90Y PET/CT. Overlap between 99mTc-MAA and 90Y-microspheres was quantified with different thresholds isocontours. The perfused volume and tumor absorbed dose were estimated using Simplicit90Y™ based on SPECT/CT and PET/CT, then compared with the supplier suggested method. These data were related to overall survival to evaluate their prognostic impact. The overlap between PET/CT and SPECT/CT was dependent on thresholds, decreasing with an increasing threshold. The overlap between the 99mTc-MAA and 90Y-microspheres biodistributions versus the tumor distribution on morphological imaging was suboptimal, in particular for small tumor volume. The tumor absorbed dose estimated after 90Y PET/CT was not different from tumor absorbed dose estimated after SPECT/CT. The Perfused lobe absorbed dose was significantly lower while the volume of the perfused lobe was significantly higher when estimated by Simplicit90Y™ compared to the supplier suggested conventional approach. A statistical parameter based on overlap between tumor and 90Y-microspheres distribution as well as tumoral dosimetry was significantly related to the overall survival. Post-treatment imaging remains paramount to estimate the irradiation dosimetry, due to an imperfect overlap. The perfused volume could be estimated from functional imaging, given its impact on dosimetry. Finally, survival seems related to tumoral overlap and dosimetry.
Identifiants
pubmed: 33254427
pii: S0753-3322(20)31057-X
doi: 10.1016/j.biopha.2020.110865
pmc: PMC9086651
mid: NIHMS1742445
pii:
doi:
Substances chimiques
Yttrium Radioisotopes
0
Yttrium-90
1K8M7UR6O1
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
110865Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103542
Pays : United States
Organisme : NCRR NIH HHS
ID : P20 RR024485
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
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