Hypothesizing the therapeutic potential of mesenchymal stem cells in oral submucous fibrosis.
Mesenchymal stem cell
Oral submucous fibrosis
Regeneration
Journal
Medical hypotheses
ISSN: 1532-2777
Titre abrégé: Med Hypotheses
Pays: United States
ID NLM: 7505668
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
07
07
2020
revised:
10
08
2020
accepted:
18
08
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
15
5
2021
Statut:
ppublish
Résumé
Oral submucous fibrosis is the direct consequence of a sustained pro-inflammatory environment characterized by excessive collagen deposition causing tissue fibrosis, and progressive degeneration of vital structures including muscle. The pathogenesis of oral submucous fibrosis is largely mediated by the pro-inflammatory, pro-fibrotic cytokines, excessive oxidative stress, abnormal angiogenesis, and epithelial to mesenchymal transition. Mesenchymal stem cells largely known for their regenerative potential have shown to have an immunomodulatory, anti-fibrotic, anti-oxidative, and angiogenic potential. Thus, mesenchymal stem cells, when introduced in an oral submucous fibrosis micro-environment, could potentially counter the progressive fibrosis. The present hypotheses discuss the various pathogenic aspects of oral submucous fibrosis and the properties of mesenchymal stem cells which could aid in halting the disease progression.
Identifiants
pubmed: 33254511
pii: S0306-9877(20)32116-2
doi: 10.1016/j.mehy.2020.110204
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110204Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.