The Immune Endocannabinoid System of the Tumor Microenvironment.
cannabinoid receptors
endocannabinoid system
immune cells
tumor microenvironment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Nov 2020
25 Nov 2020
Historique:
received:
16
10
2020
revised:
16
11
2020
accepted:
23
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
6
3
2021
Statut:
epublish
Résumé
Leukocytes are part of the tumor microenvironment (TME) and are critical determinants of tumor progression. Because of the immunoregulatory properties of cannabinoids, the endocannabinoid system (ECS) may have an important role in shaping the TME. Members of the ECS, an entity that consists of cannabinoid receptors, endocannabinoids and their synthesizing/degrading enzymes, have been associated with both tumor growth and rejection. Immune cells express cannabinoid receptors and produce endocannabinoids, thereby forming an "immune endocannabinoid system". Although in vitro effects of exogenous cannabinoids on immune cells are well described, the role of the ECS in the TME, and hence in tumor development and immunotherapy, is still elusive. This review/opinion discusses the possibility that the "immune endocannabinoid system" can fundamentally influence tumor progression. The widespread influence of cannabinoids on immune cell functions makes the members of the ECS an interesting target that could support immunotherapy.
Identifiants
pubmed: 33255584
pii: ijms21238929
doi: 10.3390/ijms21238929
pmc: PMC7728085
pii:
doi:
Substances chimiques
Cannabinoid Receptor Modulators
0
Endocannabinoids
0
Receptors, Cannabinoid
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund FWF
ID : P 30144
Pays : Austria
Organisme : Austrian Science Fund
ID : P30144
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