Physiopathological Role of Neuroactive Steroids in the Peripheral Nervous System.
chemotherapy-induced peripheral neuropathy
diabetes mellitus
pain
peripheral neuropathy
physical injury
progesterone
sex difference
steroidogenesis
testosterone
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Nov 2020
26 Nov 2020
Historique:
received:
16
10
2020
revised:
21
11
2020
accepted:
24
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
5
3
2021
Statut:
epublish
Résumé
Peripheral neuropathy (PN) refers to many conditions involving damage to the peripheral nervous system (PNS). Usually, PN causes weakness, numbness and pain and is the result of traumatic injuries, infections, metabolic problems, inherited causes, or exposure to chemicals. Despite the high prevalence of PN, available treatments are still unsatisfactory. Neuroactive steroids (i.e., steroid hormones synthesized by peripheral glands as well as steroids directly synthesized in the nervous system) represent important physiological regulators of PNS functionality. Data obtained so far and here discussed, indeed show that in several experimental models of PN the levels of neuroactive steroids are affected by the pathology and that treatment with these molecules is able to exert protective effects on several PN features, including neuropathic pain. Of note, the observations that neuroactive steroid levels are sexually dimorphic not only in physiological status but also in PN, associated with the finding that PN show sex dimorphic manifestations, may suggest the possibility of a sex specific therapy based on neuroactive steroids.
Identifiants
pubmed: 33256238
pii: ijms21239000
doi: 10.3390/ijms21239000
pmc: PMC7731236
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Neurosteroids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : MIUR "Progetto Eccellenza"
ID : -
Organisme : PON "Ricerca e Innovazione" PerMedNet
ID : ARS01_01226
Organisme : PRIN
ID : 2017ZFJCS3
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