Hypofractionated stereotactic radiotherapy for large brain metastases: Optimizing the dosimetric parameters.
Brain metastasis
Dosimetry
Dosimétrie
Métastases cérébrales
NovalisTx®
RCMI
Radiothérapie stéréotaxique
Stereotactic radiotherapy
VMAT
Journal
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
ISSN: 1769-6658
Titre abrégé: Cancer Radiother
Pays: France
ID NLM: 9711272
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
27
03
2020
revised:
14
04
2020
accepted:
27
04
2020
pubmed:
2
12
2020
medline:
12
2
2021
entrez:
1
12
2020
Statut:
ppublish
Résumé
Stereotactic radiotherapy plays a major role in the treatment of brain metastases (BM). We aimed to compare the dosimetric results of four plans for hypofractionated stereotactic radiotherapy (HFSRT) for large brain metastases. Ten patients treated with upfront NovalisTx® non-coplanar multiple dynamic conformal arcs (DCA) HFSRT for≥25mm diameter single BM were included. Three other volumetric modulated arc therapy (VMAT) treatment plans were evaluated: with coplanar arcs (Eclipse®, Varian, VMATc Better conformity indices were found with all VMAT techniques compared to DCA (1.05 vs 1.28, P<0.05). Better gradient indices were found with VMATnc NovalisTx® VMAT HFSRT for≥25mm diameter brain metastases provides the best dosimetric compromise in terms of target coverage, sparing of healthy brain tissue and low-dose delivery compared to DCA.
Identifiants
pubmed: 33257109
pii: S1278-3218(20)30289-4
doi: 10.1016/j.canrad.2020.04.011
pii:
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-7Informations de copyright
Copyright © 2020. Published by Elsevier Masson SAS.