Ferrous Iron-Dependent Pharmacology.
activity-based probes
ferritinophagy
ferroptosis
iron homeostasis
reactivity-based probes
targeted prodrugs
Journal
Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
03
08
2020
revised:
13
10
2020
accepted:
02
11
2020
pubmed:
3
12
2020
medline:
1
9
2021
entrez:
2
12
2020
Statut:
ppublish
Résumé
The recent emergence of oxidation state selective probes of cellular iron has produced a more nuanced understanding of how cells utilize this crucial nutrient to empower enzyme function, and also how labile ferrous iron contributes to iron-dependent cell death (ferroptosis) and other disease pathologies including cancer, bacterial infections, and neurodegeneration. These findings, viewed in light of the Fenton chemistry promoted by ferrous iron, suggest a new category of therapeutics exhibiting ferrous iron-dependent pharmacology. While still in its infancy, this nascent field draws inspiration from the remarkable activity and tremendous clinical impact of the antimalarial artemisinin. Here, we review recent insights into the role of labile ferrous iron in biology and disease, and describe new therapeutic approaches designed to exploit this divalent transition metal.
Identifiants
pubmed: 33261861
pii: S0165-6147(20)30253-4
doi: 10.1016/j.tips.2020.11.003
pmc: PMC7754709
mid: NIHMS1645036
pii:
doi:
Substances chimiques
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-18Subventions
Organisme : NIAID NIH HHS
ID : R01 AI105106
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA260860
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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