Dynamic Cardiolipin Synthesis Is Required for CD8

Acyltransferases / immunology Animals Barth Syndrome / immunology CD8-Positive T-Lymphocytes / cytology Cardiolipins / immunology Cells, Cultured Female Humans Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria / immunology PTEN Phosphohydrolase / immunology

Barth Syndrome CD8 T cells PTPMT1 Tafazzin cardiolipin immune memory immunometabolism mitochodria

Journal

Cell metabolism

ISSN: 1932-7420

Titre abrégé: Cell Metab

Pays: United States

ID NLM: 101233170

Informations de publication

Date de publication:
01 12 2020

Historique:

received: 25 02 2020

revised: 25 08 2020

accepted: 08 11 2020

entrez: 2 12 2020

pubmed: 3 12 2020

medline: 23 11 2021

Statut: ppublish

Résumé

Mitochondria constantly adapt to the metabolic needs of a cell. This mitochondrial plasticity is critical to T cells, which modulate metabolism depending on antigen-driven signals and environment. We show here that de novo synthesis of the mitochondrial membrane-specific lipid cardiolipin maintains CD8

Identifiants

DOI: 10.1016/j.cmet.2020.11.003 PMID: 33264603 PMC: PMC7721104

pubmed: 33264603

pii: S1550-4131(20)30598-2

doi: 10.1016/j.cmet.2020.11.003

pmc: PMC7721104

pii:

doi:

Substances chimiques

Cardiolipins 0

Acyltransferases EC 2.3.-

TAFAZZIN protein, human EC 2.3.1.-

Ptpmt1 protein, human EC 3.1.3.-

PTEN Phosphohydrolase EC 3.1.3.67

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

981-995.e7

Subventions

Organisme : Cancer Research UK

ID : A31287

Pays : United Kingdom

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of Interests E.L.P. is a SAB member of Immunomet, and E.L.P. and E.J.P. are founders of Rheos Medicines. E.L.P. is Advisory Board member of Cell and Cell Metabolism.

Références

Nat Chem Biol. 2005 Sep;1(4):223-32

pubmed: 16408039

J Neurol Sci. 1983 Dec;62(1-3):327-55

pubmed: 6142097

EMBO J. 2016 Aug 15;35(16):1793-809

pubmed: 27390127

Cells. 2019 Jul 16;8(7):

pubmed: 31315173

Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15927-32

pubmed: 15509649

J Immunol. 2012 Nov 1;189(9):4349-60

pubmed: 23028053

Elife. 2014 Nov 11;3:

pubmed: 25385531

Annu Rev Pathol. 2020 Jan 24;15:235-259

pubmed: 31585519

J Immunother Cancer. 2018 Jul 13;6(1):71

pubmed: 30005714

Cell. 2006 Jul 14;126(1):177-89

pubmed: 16839885

Nature. 2019 Jul;571(7765):403-407

pubmed: 31217581

Biochim Biophys Acta Mol Basis Dis. 2019 Apr 1;1865(4):810-821

pubmed: 30837070

Orphanet J Rare Dis. 2013 Feb 12;8:23

pubmed: 23398819

Pediatr Transplant. 2007 May;11(3):327-31

pubmed: 17430492

J Lipid Res. 2008 May;49(5):1137-46

pubmed: 18281723

PLoS One. 2015 Jun 26;10(6):e0131066

pubmed: 26114544

Immunity. 2012 Jan 27;36(1):68-78

pubmed: 22206904

Sci Immunol. 2018 Jun 22;3(24):

pubmed: 29934344

Nat Rev Immunol. 2012 Mar 22;12(4):269-81

pubmed: 22437939

Acta Paediatr. 2001 May;90(5):584-6

pubmed: 11430723

Nat Cell Biol. 2011 May;13(5):589-98

pubmed: 21478857

Mol Cell. 2019 Jun 6;74(5):877-890.e6

pubmed: 31023583

Immunity. 2013 Aug 22;39(2):311-323

pubmed: 23954133

Biochim Biophys Acta. 2012 Sep;1817(9):1588-96

pubmed: 22575443

Cell Metab. 2018 Jul 03;28(1):159-174.e11

pubmed: 29861389

PLoS One. 2013;8(3):e59267

pubmed: 23533611

J Cell Biol. 2008 Nov 17;183(4):681-96

pubmed: 19001123

Immunity. 2013 Feb 21;38(2):225-36

pubmed: 23415911

J Am Coll Cardiol. 2003 Dec 3;42(11):1994-9

pubmed: 14662265

Cell. 2017 Oct 5;171(2):385-397.e11

pubmed: 28919076

Cell. 2006 Jul 14;126(1):163-75

pubmed: 16839884

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Apr;1863(4):447-457

pubmed: 29343430

Annu Rev Physiol. 2016;78:505-31

pubmed: 26667075

Front Cell Dev Biol. 2017 Sep 29;5:90

pubmed: 29034233

Biophys J. 2011 May 4;100(9):2184-92

pubmed: 21539786

Immunity. 2019 Nov 19;51(5):856-870.e5

pubmed: 31747582

Cell Metab. 2011 Jun 8;13(6):690-700

pubmed: 21641550

Sci Adv. 2019 Mar 20;5(3):eaav1850

pubmed: 30906865

Cell. 2017 May 4;169(4):570-586

pubmed: 28475890

Biochim Biophys Acta. 2013 Mar;1831(3):582-8

pubmed: 23200781

Cell. 2016 Jun 30;166(1):63-76

pubmed: 27293185

Nat Genet. 1996 Apr;12(4):385-9

pubmed: 8630491

IUBMB Life. 2001 Sep-Nov;52(3-5):93-100

pubmed: 11798041

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8687-92

pubmed: 27382158

J Lipid Res. 2010 Apr;51(4):856-65

pubmed: 19965604

Cell. 2013 Jun 6;153(6):1239-51

pubmed: 23746840

EMBO J. 2019 Nov 15;38(22):e101056

pubmed: 31609012

Annu Rev Immunol. 2018 Apr 26;36:461-488

pubmed: 29677474

Nature. 2009 Jul 2;460(7251):103-7

pubmed: 19494812

Biochem Soc Trans. 2009 Dec;37(Pt 6):1385-8

pubmed: 19909281

Biochim Biophys Acta. 2016 Aug;1861(8 Pt A):748-54

pubmed: 27163692

Immunity. 2014 Jul 17;41(1):75-88

pubmed: 25001241

Curr Biol. 2018 Feb 19;28(4):R170-R185

pubmed: 29462587

Antioxid Redox Signal. 2014 Apr 20;20(12):1925-53

pubmed: 24094094

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8568-70

pubmed: 27439859

Nat Immunol. 2014 Dec;15(12):1152-61

pubmed: 25362489

Curr Opin Hematol. 2019 Jan;26(1):6-15

pubmed: 30451719

Nat Cell Biol. 2017 Jul;19(7):856-863

pubmed: 28628083

Cell Rep. 2015 Feb 10;10(5):694-701

pubmed: 25660020

Trends Biochem Sci. 2000 Jul;25(7):319-24

pubmed: 10871882

Cell. 2013 Sep 26;155(1):160-71

pubmed: 24055366