A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful.
Amides
/ administration & dosage
Antiviral Agents
/ administration & dosage
COVID-19
/ diagnosis
COVID-19 Testing
/ methods
Humans
Male
Middle Aged
Molecular Diagnostic Techniques
/ methods
Nasopharynx
/ virology
Nucleic Acid Amplification Techniques
/ methods
Pneumonia, Viral
/ drug therapy
Pyrazines
/ administration & dosage
RNA, Viral
/ blood
Respiration, Artificial
/ methods
SARS-CoV-2
/ isolation & purification
Treatment Outcome
Viremia
/ diagnosis
COVID-19 Drug Treatment
COVID-19
Favipiravir
Loop-mediated isothermal amplification (LAMP)
Viremia
Journal
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
ISSN: 1437-7780
Titre abrégé: J Infect Chemother
Pays: Netherlands
ID NLM: 9608375
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
21
08
2020
revised:
06
10
2020
accepted:
08
10
2020
pubmed:
4
12
2020
medline:
30
1
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
A 49-year-old Japanese male was managed by mechanical ventilation due to coronavirus disease 2019 (COVID-19) pneumonia. Favipiravir as an antiviral therapy, and anti-inflammatory treatment were administered. SARS-CoV-2 RNA was detected in serum by the loop-mediated isothermal amplification (LAMP) method on Day 9; favipiravir treatment was continued. On Day 13, negative serum RNA was confirmed, followed by mechanical ventilation was removed. On Day 23, LAMP negative was confirmed in nasopharynx, after that the patient discharged on Day 27. We could treat successfully for severe COVID-19 pneumonia based on the LAMP method. We consider this method will be useful in COVID-19 treatment.
Identifiants
pubmed: 33268271
pii: S1341-321X(20)30370-6
doi: 10.1016/j.jiac.2020.10.011
pmc: PMC7547611
pii:
doi:
Substances chimiques
Amides
0
Antiviral Agents
0
Pyrazines
0
RNA, Viral
0
favipiravir
EW5GL2X7E0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
379-383Informations de copyright
Copyright © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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