Regulatory encoding of quantitative variation in spatial activity of a
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
12
08
2020
accepted:
20
10
2020
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
15
4
2022
Statut:
epublish
Résumé
Developmental enhancers control the expression of genes prefiguring morphological patterns. The activity of an enhancer varies among cells of a tissue, but collectively, expression levels in individual cells constitute a spatial pattern of gene expression. How the spatial and quantitative regulatory information is encoded in an enhancer sequence is elusive. To link spatial pattern and activity levels of an enhancer, we used systematic mutations of the
Identifiants
pubmed: 33268361
pii: 6/49/eabe2955
doi: 10.1126/sciadv.abe2955
pmc: PMC7821883
pii:
doi:
Substances chimiques
Drosophila Proteins
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM130376
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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