Context-specific control over the neural dynamics of temporal attention by the human cerebellum.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
12 2020
Historique:
received: 31 01 2020
accepted: 15 10 2020
entrez: 3 12 2020
pubmed: 4 12 2020
medline: 15 4 2022
Statut: epublish

Résumé

Physiological methods have identified a number of signatures of temporal prediction, a core component of attention. While the underlying neural dynamics have been linked to activity within cortico-striatal networks, recent work has shown that the behavioral benefits of temporal prediction rely on the cerebellum. Here, we examine the involvement of the human cerebellum in the generation and/or temporal adjustment of anticipatory neural dynamics, measuring scalp electroencephalography in individuals with cerebellar degeneration. When the temporal prediction relied on an interval representation, duration-dependent adjustments were impaired in the cerebellar group compared to matched controls. This impairment was evident in ramping activity, beta-band power, and phase locking of delta-band activity. These same neural adjustments were preserved when the prediction relied on a rhythmic stream. Thus, the cerebellum has a context-specific causal role in the adjustment of anticipatory neural dynamics of temporal prediction, providing the requisite modulation to optimize behavior.

Identifiants

pubmed: 33268365
pii: 6/49/eabb1141
doi: 10.1126/sciadv.abb1141
pmc: PMC7821877
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS092079
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS116883
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS105839
Pays : United States

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Auteurs

Assaf Breska (A)

Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, 2121 Berkeley Way, Berkeley, CA 94720, USA. assaf.breska@berkeley.edu.

Richard B Ivry (RB)

Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, 2121 Berkeley Way, Berkeley, CA 94720, USA.

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