Endogenous Cholinergic Signaling Modulates Sound-Evoked Responses of the Medial Nucleus of the Trapezoid Body.
Acetylcholine
/ physiology
Acoustic Stimulation
Animals
Auditory Pathways
/ physiology
Female
Gerbillinae
Male
Neurons
/ physiology
Olivary Nucleus
/ physiology
Parasympathetic Nervous System
/ physiology
Pons
/ physiology
Receptors, Nicotinic
/ physiology
Sound
Trapezoid Body
/ physiology
alpha7 Nicotinic Acetylcholine Receptor
/ physiology
cholinergic projection
medial nucleus of trapezoid body
nAChRs
synaptic modulation
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
27 01 2021
27 01 2021
Historique:
received:
28
06
2020
revised:
29
10
2020
accepted:
21
11
2020
pubmed:
4
12
2020
medline:
27
3
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
The medial nucleus of trapezoid body (MNTB) is a major source of inhibition in auditory brainstem circuitry. The MNTB projects well-timed inhibitory output to principal sound-localization nuclei in the superior olive (SOC) as well as other computationally important centers. Acoustic information is conveyed to MNTB neurons through a single calyx of Held excitatory synapse arising from the cochlear nucleus. The encoding efficacy of this large synapse depends on its activity rate, which is primarily determined by sound intensity and stimulus frequency. However, MNTB activity rate is additionally influenced by inhibition and possibly neuromodulatory inputs, albeit their functional role is unclear. Happe and Morley (2004) discovered prominent expression of α7 nAChRs in rat SOC, suggesting possible engagement of ACh-mediated modulation of neural activity in the MNTB. However, the existence and nature of this putative modulation have never been physiologically demonstrated. We probed nicotinic cholinergic influences on acoustic responses of MNTB neurons from adult gerbils (
Identifiants
pubmed: 33268542
pii: JNEUROSCI.1633-20.2020
doi: 10.1523/JNEUROSCI.1633-20.2020
pmc: PMC7842756
doi:
Substances chimiques
Receptors, Nicotinic
0
alpha7 Nicotinic Acetylcholine Receptor
0
nicotinic receptor alpha4beta2
0
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
674-688Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC004391
Pays : United States
Organisme : NIDCD NIH HHS
ID : R15 DC016461
Pays : United States
Informations de copyright
Copyright © 2021 the authors.
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