The hematologic consequences of obesity.
anemia
iron deficiency
leukocytosis
thrombocytosis
venous thromboembolism
Journal
European journal of haematology
ISSN: 1600-0609
Titre abrégé: Eur J Haematol
Pays: England
ID NLM: 8703985
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
01
09
2020
revised:
28
11
2020
accepted:
01
12
2020
pubmed:
4
12
2020
medline:
30
7
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
The prevalence of obesity is increasing and progressively influencing physician-patient interactions. While there is a sizable amount of data demonstrating that obesity is a state of low-grade inflammation, to our knowledge, there is no single review summarizing its effects on hematologic parameters and thrombotic risk. We performed a literature search which largely surfaced observational studies, with a few systematic reviews and meta-analyses of these studies. We took care to review the mechanisms driving an inflammatory state and obesity's effect on white blood cells, red blood cells, platelets, and thrombotic risk. There is an observed relative, and sometimes absolute leukocytosis driven by this inflammatory state. Obesity is also associated with increased platelet counts and an increased risk for venous thromboembolism (VTE). Lastly, the association between obesity, iron deficiency (ID), and red blood cell counts may be present but remains uncertain. Recognizing the above associations may provide clinicians with reassurance regarding otherwise unexplained hematologic abnormalities in obese individuals. We hope this review will prompt future studies to further understand the underlying mechanisms driving these abnormalities and identify modifiable risk factors and potential therapeutic targets to prevent the development of probable obesity-associated conditions with significant morbidity and mortality, such as ID and VTE.
Identifiants
pubmed: 33270290
doi: 10.1111/ejh.13560
pmc: PMC8086364
mid: NIHMS1652250
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Inflammation Mediators
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
306-319Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL151367
Pays : United States
Organisme : National Institutes of Health, National Heart, Lung, and Blood Institute
ID : HL151367
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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