Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure.
COVID-19
P-selectin
myocardial injury
platelet aggregation
soluble CD40 ligand
Journal
Platelets
ISSN: 1369-1635
Titre abrégé: Platelets
Pays: England
ID NLM: 9208117
Informations de publication
Date de publication:
19 May 2021
19 May 2021
Historique:
pubmed:
4
12
2020
medline:
10
8
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
The aim of this study (NCT04343053) is to investigate the relationship between platelet activation, myocardial injury, and mortality in patients affected by Coronavirus disease 2019 (COVID-19). Fifty-four patients with respiratory failure due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were enrolled as cases. Eleven patients with the same clinical presentation, but negative for SARS-CoV-2 infection, were included as controls. Blood samples were collected at three different time points (inclusion [T1], after 7 ± 2 days [T2] and 14 ± 2 days [T3]). Platelet aggregation by light transmittance aggregometry and the circulating levels of soluble CD40 ligand (sCD40L) and
Identifiants
pubmed: 33270471
doi: 10.1080/09537104.2020.1852543
pmc: PMC7754923
doi:
Substances chimiques
Biomarkers
0
P-Selectin
0
SELP protein, human
0
CD40 Ligand
147205-72-9
Banques de données
ClinicalTrials.gov
['NCT04343053']
Types de publication
Clinical Trial
Journal Article
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM