Analysis of the effects of a tricyclic antidepressant on secondary sleep disturbance induced by chronic pain in a preclinical model.
Amitriptyline
/ pharmacology
Animals
Antidepressive Agents, Tricyclic
/ pharmacology
Chronic Pain
/ complications
Disease Models, Animal
Fluorobenzenes
/ pharmacology
Male
Mice
Neuralgia
/ complications
Piperidines
/ pharmacology
Receptor, Serotonin, 5-HT2A
/ metabolism
Serotonin 5-HT2 Receptor Antagonists
/ pharmacology
Sleep Wake Disorders
/ drug therapy
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
07
2020
accepted:
18
11
2020
entrez:
3
12
2020
pubmed:
4
12
2020
medline:
20
1
2021
Statut:
epublish
Résumé
Chronic pain and sleep have a bidirectional relationship that promotes a vicious circle making chronic pain more difficult to treat. Therefore, pain and sleep should be treated simultaneously. In our previous study, we suggested that hyperactivation of ascending serotonergic neurons could cause secondary sleep disturbance in chronic pain. This study aimed to demonstrate the effects of a tricyclic antidepressant (amitriptyline) and a selective 5-hydroxy-tryptamine 2A (5-HT2A) antagonist (MDL 100907) that adjust serotonergic transmission, on secondary sleep disturbance induced in a preclinical chronic pain model. We produced a chronic neuropathic pain model by partial sciatic nerve ligation in mice, analyzed their electroencephalogram (EEG) and electromyogram (EMG) using the SleepSign software, and evaluated the sleep condition of the pain model mice after administration of amitriptyline or MDL 100907. Amitriptyline improved thermal hyperalgesia and the amount of sleep, especially non-REM sleep. Time change of normalized power density of δ wave in the nerve ligation group with amitriptyline administration showed a normal pattern that was similar to sham mice. In addition, MDL 100907 normalized sleep condition similar to amitriptyline, without improvement in pain threshold. In conclusion, amitriptyline could improve sleep quantity and quality impaired by chronic pain. 5-HT2A receptor antagonism could partially contribute to this sleep improvement, but is not associated with pain relief.
Identifiants
pubmed: 33270791
doi: 10.1371/journal.pone.0243325
pii: PONE-D-20-20832
pmc: PMC7714178
doi:
Substances chimiques
Antidepressive Agents, Tricyclic
0
Fluorobenzenes
0
Htr2a protein, mouse
0
Piperidines
0
Receptor, Serotonin, 5-HT2A
0
Serotonin 5-HT2 Receptor Antagonists
0
Amitriptyline
1806D8D52K
volinanserin
EW71EE171J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0243325Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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