Clinicopathological Staging of Dynamics of Neurodegeneration and Neuronal Loss in Alzheimer Disease.
Alzheimer disease
Clinicopathological staging
GDS/FAST
Neurofibrillary degeneration
Neuronal loss
Journal
Journal of neuropathology and experimental neurology
ISSN: 1554-6578
Titre abrégé: J Neuropathol Exp Neurol
Pays: England
ID NLM: 2985192R
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
pubmed:
4
12
2020
medline:
22
6
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
Clinical and neuropathological staging of Alzheimer disease (AD) neurodegeneration and neuronal loss dynamics is the baseline for identification of treatment targets and timing. The aim of this study of 14 brain regions in 25 subjects diagnosed with AD and 13 age-matched control subjects was to establish the pattern of neurodegeneration, and the severity and rate of neuronal loss in mild cognitive impairment/mild AD (Functional Assessment Staging [FAST] test 3-4), moderate to moderately severe AD (FAST 5-6), and severe AD (FAST 7). The study revealed (1) the most severe neuronal loss in FAST 3-4; (2) the highest rate of neuronal loss in FAST 5-6, to the "critical" point limiting further increase in neuronal loss; (3) progression of neurofibrillary degeneration, but decline of neuronal loss to a floor level in FAST 7; and (4) structure-specific rate of neuronal loss caused by neurofibrillary degeneration and a large pool of neuronal loss caused by other mechanisms. This study defines a range and speed of progression of AD pathology and functional decline that might potentially be prevented by the arrest of neuronal loss, both related and unrelated to neurofibrillary degeneration, during the 9-year duration of mild cognitive impairment/mild AD.
Identifiants
pubmed: 33270870
pii: 6019941
doi: 10.1093/jnen/nlaa140
pmc: PMC7749716
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-44Subventions
Organisme : NIA NIH HHS
ID : P01 AG060882
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066512
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD043960
Pays : United States
Informations de copyright
© 2020 American Association of Neuropathologists, Inc. All rights reserved.
Références
Acta Neuropathol. 1991;82(4):239-59
pubmed: 1759558
Am J Pathol. 1990 Dec;137(6):1383-92
pubmed: 1701963
Science. 1984 Sep 14;225(4667):1168-70
pubmed: 6474172
Arch Neurol. 2004 Jan;61(1):59-66
pubmed: 14732621
J Biol Chem. 2001 Sep 28;276(39):36337-43
pubmed: 11470789
Br J Psychiatry. 1982 Jun;140:566-72
pubmed: 7104545
J Neurosci. 2006 Jul 19;26(29):7674-9
pubmed: 16855095
Lancet. 1994 Sep 17;344(8925):769-72
pubmed: 7916070
Int J Clin Exp Pathol. 2011 Jan 30;4(2):147-55
pubmed: 21326809
Arch Neurol. 2002 Nov;59(11):1764-7
pubmed: 12433264
Neurobiol Aging. 2006 Feb;27(2):270-7
pubmed: 16399212
Aging Cell. 2012 Dec;11(6):996-1004
pubmed: 22882466
J Neuropathol Exp Neurol. 1997 Apr;56(4):414-20
pubmed: 9100672
Sci Rep. 2020 Sep 3;10(1):14579
pubmed: 32883971
Brain. 2016 Nov 1;139(11):2983-2993
pubmed: 27694152
Am J Pathol. 2008 Jul;173(1):182-94
pubmed: 18535185
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Acta Neuropathol. 2002 Apr;103(4):363-9
pubmed: 11904756
Neurology. 2003 May 13;60(9):1495-500
pubmed: 12743238
Alzheimers Dement. 2015 Jun;11(6):700-9
pubmed: 25510383
J Neuropathol Exp Neurol. 2012 May;71(5):362-81
pubmed: 22487856
Ann Neurol. 1997 Jan;41(1):17-24
pubmed: 9005861
Ann Neurol. 1985 Mar;17(3):278-82
pubmed: 3158266
J Comp Neurol. 1990 Jun 1;296(1):1-22
pubmed: 2358525
J Geriatr Psychiatry Neurol. 1999 Winter;12(4):168-79
pubmed: 10616864
Alzheimers Res Ther. 2009 Oct 12;1(2):5
pubmed: 19822029
Acta Neuropathol. 2000 Oct;100(4):356-64
pubmed: 10985692
Dement Geriatr Cogn Disord. 2006;22(4):312-9
pubmed: 16940725
Acta Neuropathol. 2002 Apr;103(4):370-6
pubmed: 11904757
Ann Neurol. 1986 Oct;20(4):472-81
pubmed: 3789663
Aging (Albany NY). 2019 Aug 30;11(16):6175-6198
pubmed: 31469660
Psychopharmacol Bull. 1988;24(4):653-9
pubmed: 3249767
Neurology. 2008 May 6;70(19 Pt 2):1850-7
pubmed: 18401022
J Cell Biol. 2013 May 13;201(4):613-29
pubmed: 23649808
Brain Res. 1998 Jul 13;799(1):156-8
pubmed: 9666111
J Neurosci. 2003 Apr 1;23(7):2557-63
pubmed: 12684440
Aging Cell. 2018 Dec;17(6):e12840
pubmed: 30126037
Nat Commun. 2019 Aug 21;10(1):3758
pubmed: 31434879
Acta Neuropathol. 2014;127(6):811-24
pubmed: 24659241
J Neuropathol Exp Neurol. 2017 Jun 1;76(6):439-457
pubmed: 28505333
J Intellect Disabil Res. 2014 Jan;58(1):61-70
pubmed: 23902161
AJNR Am J Neuroradiol. 1993 Jul-Aug;14(4):897-906
pubmed: 8352162
Brain. 1991 Oct;114 ( Pt 5):2283-301
pubmed: 1933245
J Neuropathol Exp Neurol. 2012 Aug;71(8):694-701
pubmed: 22805771
J Neuropathol Exp Neurol. 1999 Feb;58(2):188-97
pubmed: 10029101
Int Psychogeriatr. 2006 Sep;18(3):394-402; discussion 409-14
pubmed: 16867203
Dev Disabil Res Rev. 2013;18(1):51-67
pubmed: 23949829
Neurobiol Aging. 1997 Jul-Aug;18(4):351-7
pubmed: 9330961
Am J Pathol. 2011 Sep;179(3):1373-84
pubmed: 21777559
Arch Neurol. 2006 May;63(5):674-81
pubmed: 16682537
Biochem Pharmacol. 2014 Apr 15;88(4):499-507
pubmed: 24412277
Brain Res. 1989 Jan 16;477(1-2):90-9
pubmed: 2495152
Biochem Biophys Res Commun. 2010 Jun 11;396(4):866-9
pubmed: 20457127
Proc Natl Acad Sci U S A. 1986 Jul;83(13):4913-7
pubmed: 3088567
Am J Pathol. 1991 Sep;139(3):599-607
pubmed: 1716046
Int Psychogeriatr. 2001 Jun;13(2):163-81
pubmed: 11495392
Nature. 2018 Oct;562(7728):578-582
pubmed: 30232451
J Am Geriatr Soc. 1999 Apr;47(4):463-9
pubmed: 10203123
Mol Neurodegener. 2018 Mar 1;13(1):11
pubmed: 29490706
Neurobiol Aging. 2001 Jan-Feb;22(1):49-61
pubmed: 11164276
J Neurosci. 1996 Jul 15;16(14):4491-500
pubmed: 8699259
Neurobiol Aging. 1999 May-Jun;20(3):259-69
pubmed: 10588573
Neurobiol Aging. 1990 Jan-Feb;11(1):3-13
pubmed: 2183081
J Neurosci. 1998 Apr 15;18(8):2801-7
pubmed: 9525997
Nat Neurosci. 2019 May;22(5):719-728
pubmed: 30936558
Neurology. 1992 Mar;42(3 Pt 1):631-9
pubmed: 1549228
Exp Neurol. 2005 May;193(1):198-206
pubmed: 15817278
Acta Neuropathol. 1991;83(1):21-9
pubmed: 1724335
Dement Geriatr Cogn Disord. 2004;18(1):87-93
pubmed: 15087583
Am J Pathol. 1997 Jun;150(6):1933-9
pubmed: 9176387
Acta Neuropathol. 2003 Apr;105(4):393-402
pubmed: 12624793
J Neurosci. 1997 May 15;17(10):3588-98
pubmed: 9133382
Int Psychogeriatr. 1996 Summer;8(2):159-93
pubmed: 8994889
Arch Neurol. 2006 Jan;63(1):38-46
pubmed: 16401735
Arch Neurol. 1991 Feb;48(2):148-54
pubmed: 1993005
Acta Neuropathol. 2008 Aug;116(2):215-20
pubmed: 18592255
J Neurol Sci. 1989 Feb;89(2-3):169-79
pubmed: 2522541