A metabolomic study of cervical dystonia.

Adult Aged Carbohydrate Metabolism Case-Control Studies Female Gas Chromatography-Mass Spectrometry Humans Lipid Metabolism Male Metabolomics Middle Aged Torticollis / blood
Cervical dystonia MWAS Metabolomics Torticollis

Journal

Parkinsonism & related disorders
ISSN: 1873-5126
Titre abrégé: Parkinsonism Relat Disord
Pays: England
ID NLM: 9513583

Informations de publication

Date de publication:
01 2021
Historique:
received: 15 07 2020
revised: 26 10 2020
accepted: 21 11 2020
pubmed: 4 12 2020
medline: 23 11 2021
entrez: 3 12 2020
Statut: ppublish

Résumé

Cervical dystonia is the most common of the adult-onset focal dystonias. Most cases are idiopathic. The current view is that cervical dystonia may be caused by some combination of genetic and environmental factors. Genetic contributions have been studied extensively, but there are few studies of other factors. We conducted an exploratory metabolomics analysis of cervical dystonia to identify potentially abnormal metabolites or altered biological pathways. Plasma samples from 100 cases with idiopathic cervical dystonia and 100 controls were compared using liquid chromatography coupled with mass spectrometry-based metabolomics. A total of 7346 metabolic features remained after quality control, and up to 289 demonstrated significant differences between cases and controls, depending on statistical criteria chosen. Pathway analysis revealed 9 biological processes to be significantly associated at p < 0.05, 5 pathways were related to carbohydrate metabolism, 3 pathways were related to lipid metabolism. This is the first large scale metabolomics study for any type of dystonia. The results may provide potential novel insights into the biology of cervical dystonia.

Identifiants

DOI: 10.1016/j.parkreldis.2020.11.020 PMID: 33271463 PMC: PMC7856090
pubmed: 33271463
pii: S1353-8020(20)30872-5
doi: 10.1016/j.parkreldis.2020.11.020
pmc: PMC7856090
mid: NIHMS1650912
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

98-103

Subventions

Organisme : NINDS NIH HHS
ID : R21 NS096455
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS116025
Pays : United States
Organisme : NCATS NIH HHS
ID : U54 TR001456
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Chang Liu (C)

Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA. Electronic address: chang.liu2@emory.edu.

Laura Scorr (L)

Jean and Paul Amos Parkinson's Disease and Movement Disorder Clinic Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: laura.m.scorr@emory.edu.

Gamze Kilic-Berkmen (G)

Jean and Paul Amos Parkinson's Disease and Movement Disorder Clinic Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: gamze.kilic.berkmen@emory.edu.

Adam Cotton (A)

Jean and Paul Amos Parkinson's Disease and Movement Disorder Clinic Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: akassem@emory.edu.

Stewart A Factor (SA)

Jean and Paul Amos Parkinson's Disease and Movement Disorder Clinic Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: sfactor@emory.edu.

Alan Freeman (A)

Jean and Paul Amos Parkinson's Disease and Movement Disorder Clinic Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: afreema@emory.edu.

ViLinh Tran (V)

Clinical Biomarkers Laboratory, Department of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: vilinh.tran@emory.edu.

Ken Liu (K)

Clinical Biomarkers Laboratory, Department of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: ken.liu@emory.edu.

Karan Uppal (K)

Department of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: kuppal2@emory.edu.

Dean Jones (D)

Department of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: dpjones@emory.edu.

H A Jinnah (HA)

Jean and Paul Amos Parkinson's Disease and Movement Disorder Clinic Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: hjinnah@emory.edu.

Yan V Sun (YV)

Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: yan.v.sun@emory.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › A metabolomic study of cervical dystonia.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › A metabolomic study of cervical dystonia.
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › A metabolomic study of cervical dystonia.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › A metabolomic study of cervical dystonia.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Chromatographie gazeuse-spectrométrie de masse › A metabolomic study of cervical dystonia.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A metabolomic study of cervical dystonia.
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › A metabolomic study of cervical dystonia.
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › A metabolomic study of cervical dystonia.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › A metabolomic study of cervical dystonia.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Dyskinésies › Dystonie › Torticolis › A metabolomic study of cervical dystonia.