Response to iron overload in cultured hepatocytes.

Adenylate Kinase / metabolism Animals Cell Survival / drug effects Cells, Cultured Chlorides / pharmacology Ferric Compounds / pharmacology Ferroptosis / drug effects Gene Ontology Hep G2 Cells Hepatocytes / drug effects Humans Iron / pharmacology Iron Overload / genetics Male Mice Microtubule-Associated Proteins / metabolism Mitophagy / drug effects Necrosis Rats, Sprague-Dawley Signal Transduction / drug effects

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
03 12 2020
Historique:
received: 18 03 2020
accepted: 19 11 2020
entrez: 4 12 2020
pubmed: 5 12 2020
medline: 17 3 2021
Statut: epublish

Résumé

Iron is essential for a variety of physiological processes. Hepatic iron overload acts as a trigger for the progression of hepatic steatosis to nonalcoholic steatohepatitis and hepatocellular carcinoma. In the present study, we aimed to study the effects of iron overload on cellular responses in hepatocytes. Rat primary hepatocytes (RPH), mouse primary hepatocytes (MPH), HepG2 human hepatoma cells and Hepa1-6 mouse hepatoma cells were treated with FeCl

Identifiants

DOI: 10.1038/s41598-020-78026-6 PMID: 33273573 PMC: PMC7713074
pubmed: 33273573
doi: 10.1038/s41598-020-78026-6
pii: 10.1038/s41598-020-78026-6
pmc: PMC7713074
doi:

Substances chimiques

Chlorides 0
Ferric Compounds 0
MAP1LC3A protein, human 0
Microtubule-Associated Proteins 0
Iron E1UOL152H7
Adenylate Kinase EC 2.7.4.3
ferric chloride U38V3ZVV3V

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

21184

Références

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Auteurs

Hsuan-Ju Chen (HJ)

Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwakecho, Kyoto, 606-8502, Japan.

Makoto Sugiyama (M)

Laboratory of Veterinary Anatomy, Kitasato University School of Veterinary Medicine, Towada, 034-8628, Japan.

Fumie Shimokawa (F)

Laboratory of Molecular Biology, Azabu University School of Veterinary Medicine, Sagamihara, 252-5201, Japan.

Masaru Murakami (M)

Laboratory of Molecular Biology, Azabu University School of Veterinary Medicine, Sagamihara, 252-5201, Japan.

Osamu Hashimoto (O)

Laboratory of Experimental Animal Science, Kitasato University School of Veterinary Medicine, Towada, 034-8628, Japan.
Department of Animal Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, 526-0829, Japan.

Tohru Matsui (T)

Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwakecho, Kyoto, 606-8502, Japan.

Masayuki Funaba (M)

Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwakecho, Kyoto, 606-8502, Japan. funaba.masayuki.8w@kyoto-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Phosphate Group Acceptor) › Adenylate kinase › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Eucaryotes › Animaux › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Cellules › Cellules cultivées › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Chlorures › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Produits chimiques inorganiques › Composés du fer › Composés du fer III › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Ferroptose › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Vocabulaire contrôlé › Ontologies biologiques › Gene Ontology › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du fer › Surcharge en fer › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Renouvellement des mitochondries › Dégradation des mitochondries › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Response to iron overload in cultured hepatocytes.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Response to iron overload in cultured hepatocytes.