Cardioprotective Effects of Taurisolo® in Cardiomyoblast H9c2 Cells under High-Glucose and Trimethylamine N-Oxide Treatment
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
06
2020
revised:
21
09
2020
accepted:
24
10
2020
entrez:
4
12
2020
pubmed:
5
12
2020
medline:
21
5
2021
Statut:
epublish
Résumé
In addition to high plasma glucose, increased levels of trimethylamine N-oxide (TMAO) have been found in obese subjects, where are considered as a novel risk factor for cardiovascular diseases. The present study aimed to investigate the effect of a novel nutraceutical formulation based on grape polyphenols (registered as Taurisolo®) in counteracting TMAO- and high glucose (HG)-induced cytotoxicity in cardiomyoblast H9c2 cells. Cell damage was induced with HG (HG-H9c2) and HG+TMAO (THG-H9c2); both experimental cell models were, thus, incubated for 72 h in the presence or absence of Taurisolo®. It was observed that Taurisolo® significantly increased the cell viability and reduced lactate dehydrogenase and aspartate transaminase release in both HG- and THG-H9c2 cells. Additionally, through its antioxidant activity, Taurisolo® modulated cell proliferation
Identifiants
pubmed: 33273998
doi: 10.1155/2020/2961406
pmc: PMC7683148
doi:
Substances chimiques
Cardiotonic Agents
0
Methylamines
0
Sphingolipids
0
trimethyloxamine
FLD0K1SJ1A
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2961406Informations de copyright
Copyright © 2020 Stefania Lama et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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