Immunomodulatory drugs in multiple myeloma: Impact of the SCARMET (Self CARe and MEdication Toxicity) educational intervention on outpatients' knowledge to manage adverse effects.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
06
2020
accepted:
18
11
2020
entrez:
4
12
2020
pubmed:
5
12
2020
medline:
20
1
2021
Statut:
epublish
Résumé
Long-term multiple myeloma therapy by immunomodulatory drugs (IMiDs) raises the question of management of adverse effects. The aim of this study is to assess the impact of an educational session for patients on the acquisition of knowledge to manage hematologic and thromboembolic adverse effects of IMiDs. In this prospective single-center study, patients attended an educational session with a hospital clinical pharmacist and a nurse. The primary endpoint was the patient's level of knowledge for the management of IMiDs adverse effects, assess with a dedicated questionnaire administered before the session then 1 and 6 months after. Assessment of knowledge was combined with self-assessment of certainty. The secondary endpoints were adherence and IMiD treatment satisfaction. 50 patients were included. Patient knowledge increased at 1 month (p<0.001) despite a loss of knowledge at 6 months (p<0.05). Six months after the educational intervention, the number of patients with skills considered satisfactory by the pharmacist and nurse increased (p<0.01). Most patients showed satisfactory adherence, with medication possession ratio ≥ 80%. The Self CARe and MEdication Toxicity (SCARMET) study highlighted the impact of multidisciplinary follow-up in multiple myeloma patients to improve knowledge of toxicity self-management.
Identifiants
pubmed: 33275634
doi: 10.1371/journal.pone.0243309
pii: PONE-D-20-16887
pmc: PMC7717911
doi:
Substances chimiques
Immunologic Factors
0
Types de publication
Clinical Trial
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0243309Déclaration de conflit d'intérêts
No authors have competing interests.
Références
Curr Med Res Opin. 2009 Sep;25(9):2303-10
pubmed: 19635045
Value Health. 2008 Sep-Oct;11(5):913-26
pubmed: 18494753
Value Health. 2013 Jan-Feb;16(1):88-96
pubmed: 23337219
Patient Prefer Adherence. 2016 Aug 24;10:1609-21
pubmed: 27601886
Cancer Nurs. 2013 Jan-Feb;36(1):18-28
pubmed: 23235499
PLoS One. 2013;8(2):e56247
pubmed: 23437104
JAMA. 2017 Jul 11;318(2):197-198
pubmed: 28586821
J Med Econ. 2016;19(4):397-402
pubmed: 26652728
PLoS One. 2019 Mar 27;14(3):e0214446
pubmed: 30917164
Psychooncology. 2016 Nov;25(11):1308-1316
pubmed: 26403252
J Clin Nurs. 2018 Apr;27(7-8):e1485-e1493
pubmed: 29345011
Palliat Med. 2001 Sep;15(5):379-86
pubmed: 11591089
Patient Educ Couns. 2003 Sep;51(1):29-37
pubmed: 12915277
Ann Hematol. 2018 Mar;97(3):387-400
pubmed: 29282494
N Engl J Med. 2007 Nov 22;357(21):2123-32
pubmed: 18032762
J Clin Oncol. 2009 Dec 20;27(36):6191-8
pubmed: 19917849
Leuk Lymphoma. 2015 Feb;56(2):407-14
pubmed: 24738975
J Oncol Pract. 2017 May;13(5):e474-e485
pubmed: 28398843
Cancer. 2007 Jan 15;109(2 Suppl):414-24
pubmed: 17173280
Support Care Cancer. 2019 Nov;27(11):4265-4271
pubmed: 30859307
Soc Sci Med. 1997 Dec;45(12):1829-43
pubmed: 9447632
J Clin Oncol. 2008 Nov 20;26(33):5450-7
pubmed: 18936478
Adv Ther. 2005 Jul-Aug;22(4):313-56
pubmed: 16418141
J Clin Oncol. 2017 Oct 10;35(29):3306-3314
pubmed: 28541791
Leuk Res. 2011 May;35(5):626-30
pubmed: 21095002
J Adv Pract Oncol. 2014 Jul-Aug;5(4):269-79
pubmed: 26110071
Oncology. 2015;88(1):1-8
pubmed: 25247774
Asia Pac J Oncol Nurs. 2014 Apr-Jun;1(1):46-49
pubmed: 27981082
Support Care Cancer. 2010 May;18(5):583-90
pubmed: 19590904
J Geriatr Oncol. 2017 Jul;8(4):296-302
pubmed: 28506543
Blood. 2009 May 28;113(22):5401-11
pubmed: 19349618
Value Health. 2008 Jan-Feb;11(1):44-7
pubmed: 18237359
Patient Educ Couns. 2005 Jan;56(1):98-103
pubmed: 15590229
Med Pharm Rep. 2019 Apr;92(2):117-122
pubmed: 31086837
CA Cancer J Clin. 2009 Jan-Feb;59(1):56-66
pubmed: 19147869
Diabetes Nutr Metab. 2000 Oct;13(5):276-83
pubmed: 11105970
Gerontologist. 2005 Aug;45(4):545-52
pubmed: 16051918
J Clin Oncol. 2015 Sep 10;33(26):2863-9
pubmed: 26240224
N Engl J Med. 2005 Aug 4;353(5):487-97
pubmed: 16079372